Detailed information of TA system TA059695

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1662734..1663313
• Replicon: chromosome
• Accession: NZ_CP013955
• Organism: Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ASL15_RS08185
• Protein ID: WP_001025401.1
• Coordinates: 1663068..1663313 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1662734..1663099 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL15_RS08145	1659478..1660035	-	558	WP_000645045.1	DUF2815 family protein	-
ASL15_RS08150	1660061..1661227	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
ASL15_RS08155	1661224..1661586	-	363	WP_000279445.1	hypothetical protein	-
ASL15_RS08160	1661601..1661924	-	324	WP_000174995.1	hypothetical protein	-
ASL15_RS08165	1662003..1662164	-	162	WP_015986189.1	DUF1270 family protein	-
ASL15_RS08170	1662176..1662439	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
ASL15_RS08175	1662464..1662679	-	216	WP_001097552.1	hypothetical protein	-
ASL15_RS08180	1662734..1663099	+	366	WP_001128433.1	hypothetical protein	Antitoxin
ASL15_RS08185	1663068..1663313	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ASL15_RS08190	1663369..1663578	+	210	WP_000642492.1	hypothetical protein	-
ASL15_RS08195	1663568..1663711	-	144	WP_000939498.1	hypothetical protein	-
ASL15_RS08200	1663726..1664169	-	444	WP_044414793.1	hypothetical protein	-
ASL15_RS08205	1664193..1664414	-	222	WP_031887876.1	DUF739 family protein	-
ASL15_RS08210	1664575..1665345	+	771	WP_031887877.1	helix-turn-helix domain-containing protein	-
ASL15_RS15860	1665357..1665503	+	147	WP_001049401.1	hypothetical protein	-
ASL15_RS08215	1665500..1665685	+	186	WP_000109189.1	hypothetical protein	-
ASL15_RS08220	1665755..1665922	+	168	WP_000705241.1	hypothetical protein	-
ASL15_RS08225	1666062..1666766	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
ASL15_RS08230	1666977..1668182	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1623389..1680934	57545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T59695 WP_001025401.1 NZ_CP013955:c1663313-1663068 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T59695 NZ_CP013955:c1663313-1663068 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT59695 NZ_CP013955:1662734-1663099 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin