Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 400104..400762 Replicon chromosome
Accession NZ_CP013949
Organism Bradyrhizobium sp. CCGE-LA001

Toxin (Protein)


Gene name vapC Uniprot ID A0A109Q9G4
Locus tag BCCGELA001_RS01920 Protein ID WP_008538955.1
Coordinates 400104..400508 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0X8CD57
Locus tag BCCGELA001_RS01925 Protein ID WP_008538952.1
Coordinates 400508..400762 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCCGELA001_RS01900 395410..397980 - 2571 WP_060734492.1 FtsX-like permease family protein -
BCCGELA001_RS01905 397977..398699 - 723 WP_060734493.1 ABC transporter ATP-binding protein -
BCCGELA001_RS01910 398755..399390 + 636 WP_060737442.1 arylesterase -
BCCGELA001_RS01915 399563..400099 + 537 WP_008538959.1 RNA 2',3'-cyclic phosphodiesterase -
BCCGELA001_RS01920 400104..400508 - 405 WP_008538955.1 type II toxin-antitoxin system VapC family toxin Toxin
BCCGELA001_RS01925 400508..400762 - 255 WP_008538952.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCCGELA001_RS01930 400958..402142 + 1185 WP_008538950.1 cell division protein ZapE -
BCCGELA001_RS01935 402383..403351 + 969 WP_025032846.1 malate dehydrogenase -
BCCGELA001_RS01940 403560..404756 + 1197 WP_008538940.1 ADP-forming succinate--CoA ligase subunit beta -
BCCGELA001_RS01945 404761..405240 + 480 WP_008538937.1 DUF1579 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14392.33 Da        Isoelectric Point: 4.7250

>T59641 WP_008538955.1 NZ_CP013949:c400508-400104 [Bradyrhizobium sp. CCGE-LA001]
MVIDTSAIMAIALNENDAAGIERLIADDPIRLISAATVLEATMVIETRLGDAGGREFDLWLVKIGAEVVAVDTVQADAAR
RAWRRYGKGHHAASLNYGDCFSYALAITSNEPLLFKGEDFAKTDVRRAGATPQG

Download         Length: 405 bp

>T59641 NZ_CP013949:c400508-400104 [Bradyrhizobium sp. CCGE-LA001]
ATGGTGATCGACACATCGGCGATCATGGCCATCGCACTCAACGAAAACGATGCAGCCGGTATTGAGCGGCTGATCGCGGA
CGATCCGATCCGCCTGATCTCAGCGGCAACAGTGCTCGAAGCAACGATGGTGATCGAGACGCGGCTGGGTGATGCAGGCG
GCCGTGAGTTCGATCTCTGGCTCGTGAAGATCGGCGCCGAGGTCGTGGCTGTCGATACCGTGCAAGCCGACGCAGCGCGA
CGCGCCTGGCGACGCTACGGCAAAGGACACCACGCCGCGTCGCTCAACTACGGTGACTGCTTTTCCTACGCGCTCGCGAT
CACGAGCAACGAACCACTGCTGTTCAAAGGCGAAGACTTCGCGAAGACCGACGTCCGCCGGGCAGGCGCGACGCCGCAGG
GATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9660.93 Da        Isoelectric Point: 5.2273

>AT59641 WP_008538952.1 NZ_CP013949:c400762-400508 [Bradyrhizobium sp. CCGE-LA001]
MALSIKDPETEQLARSLAQLTGENITTATKRAIEERLRRLGGQARKDALLEDMAEIRRRWSEMRALDDRTPEEILGYDEH
GLPR

Download         Length: 255 bp

>AT59641 NZ_CP013949:c400762-400508 [Bradyrhizobium sp. CCGE-LA001]
ATGGCGCTGAGCATCAAGGACCCCGAAACGGAGCAATTGGCGCGAAGTCTCGCGCAATTGACCGGCGAGAACATCACGAC
CGCCACCAAGCGCGCCATCGAGGAGCGATTGCGCCGGCTCGGCGGTCAAGCTCGCAAGGACGCGCTGCTCGAAGACATGG
CGGAGATCAGGCGACGCTGGAGCGAAATGCGAGCCTTGGACGATCGCACGCCCGAAGAAATTCTCGGATACGACGAGCAC
GGATTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109Q9G4

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8CD57

References