Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 163557..164200 Replicon plasmid p3PS13
Accession NZ_CP013804
Organism Piscirickettsia salmonis strain PM22180B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag AVM70_RS17860 Protein ID WP_027242931.1
Coordinates 163793..164200 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag AVM70_RS17855 Protein ID WP_027242932.1
Coordinates 163557..163784 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVM70_RS17835 159488..160054 - 567 WP_017375966.1 HAMP domain-containing histidine kinase -
AVM70_RS19780 160199..160717 - 519 WP_155048090.1 hypothetical protein -
AVM70_RS17840 160668..161093 - 426 WP_017375964.1 hypothetical protein -
AVM70_RS17845 161364..162359 - 996 WP_036817204.1 hypothetical protein -
AVM70_RS17850 163059..163424 + 366 WP_026063496.1 hypothetical protein -
AVM70_RS17855 163557..163784 + 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AVM70_RS17860 163793..164200 + 408 WP_027242931.1 DUF4411 family protein Toxin
AVM70_RS17865 164346..165728 + 1383 WP_027242930.1 hypothetical protein -
AVM70_RS19785 165918..166121 + 204 WP_017375952.1 hypothetical protein -
AVM70_RS17870 166317..166700 + 384 WP_027242929.1 HNH endonuclease -
AVM70_RS17875 166787..167269 + 483 WP_075278733.1 P27 family phage terminase small subunit -
AVM70_RS17880 167272..168603 + 1332 WP_048876205.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..181038 181038


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T59358 WP_027242931.1 NZ_CP013804:163793-164200 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T59358 NZ_CP013804:163793-164200 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT59358 WP_027242932.1 NZ_CP013804:163557-163784 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT59358 NZ_CP013804:163557-163784 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References