Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 111194..111730 Replicon plasmid p1PS2
Accession NZ_CP013763
Organism Piscirickettsia salmonis strain PM21567A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI49_RS16290 Protein ID WP_016211910.1
Coordinates 111194..111466 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI49_RS16295 Protein ID WP_032126795.1
Coordinates 111470..111730 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI49_RS16260 106381..106755 - 375 WP_016212499.1 hypothetical protein -
AVI49_RS16265 107092..107694 - 603 Protein_146 IS30 family transposase -
AVI49_RS16275 107754..108907 + 1154 WP_105962623.1 IS3 family transposase -
AVI49_RS16280 108916..109314 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
AVI49_RS16285 109747..110868 + 1122 WP_016211913.1 hypothetical protein -
AVI49_RS16290 111194..111466 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI49_RS16295 111470..111730 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI49_RS19110 112030..112218 - 189 WP_155053508.1 hypothetical protein -
AVI49_RS16305 112453..112881 + 429 WP_075273782.1 site-specific integrase -
AVI49_RS17985 113151..113390 + 240 WP_075275277.1 transposase zinc-binding domain-containing protein -
AVI49_RS16315 113315..114286 + 972 WP_033923677.1 IS91 family transposase -
AVI49_RS16320 114425..115132 + 708 WP_075273780.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120730 120730
- flank IS/Tn - - 114425..115132 707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59314 WP_016211910.1 NZ_CP013763:c111466-111194 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59314 NZ_CP013763:c111466-111194 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59314 WP_032126795.1 NZ_CP013763:c111730-111470 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59314 NZ_CP013763:c111730-111470 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References