Detailed information of TA system TA059018

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1569908..1570487
• Replicon: chromosome
• Accession: NZ_CP013616
• Organism: Staphylococcus aureus strain RIVM1295

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: AUC48_RS07625
• Protein ID: WP_001025401.1
• Coordinates: 1570242..1570487 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1569908..1570273 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUC48_RS07570	1565619..1566290	-	672	WP_031838379.1	phi PV83 orf 19-like protein	-
AUC48_RS07575	1566303..1566857	-	555	WP_000704713.1	single-stranded DNA-binding protein	-
AUC48_RS07580	1566887..1567666	-	780	WP_000137071.1	ATP-binding protein	-
AUC48_RS07585	1567667..1568203	-	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
AUC48_RS07590	1568216..1568476	-	261	WP_000291481.1	DUF1108 family protein	-
AUC48_RS07595	1568481..1568783	-	303	WP_031838380.1	DUF2482 family protein	-
AUC48_RS07600	1568848..1569162	-	315	WP_031838381.1	hypothetical protein	-
AUC48_RS07605	1569167..1569337	-	171	WP_031838382.1	DUF1270 domain-containing protein	-
AUC48_RS07610	1569350..1569613	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
AUC48_RS07615	1569638..1569853	-	216	WP_001097552.1	hypothetical protein	-
AUC48_RS07620	1569908..1570273	+	366	WP_016170627.1	hypothetical protein	Antitoxin
AUC48_RS07625	1570242..1570487	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
AUC48_RS07630	1570543..1570752	+	210	WP_000642492.1	hypothetical protein	-
AUC48_RS07635	1570742..1570885	-	144	WP_000939498.1	hypothetical protein	-
AUC48_RS07640	1570956..1571168	+	213	WP_000362644.1	hypothetical protein	-
AUC48_RS14810	1571209..1571358	-	150	WP_000771849.1	hypothetical protein	-
AUC48_RS07645	1571373..1571816	-	444	WP_000435362.1	hypothetical protein	-
AUC48_RS07650	1571829..1572077	-	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
AUC48_RS07655	1572241..1572564	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	-
AUC48_RS07660	1572577..1573038	+	462	WP_000525004.1	hypothetical protein	-
AUC48_RS07665	1573056..1573640	+	585	WP_000825948.1	hypothetical protein	-
AUC48_RS07670	1573870..1574016	+	147	WP_001795334.1	hypothetical protein	-
AUC48_RS07675	1574013..1574627	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1530962..1593589	62627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T59018 WP_001025401.1 NZ_CP013616:c1570487-1570242 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T59018 NZ_CP013616:c1570487-1570242 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT59018 NZ_CP013616:1569908-1570273 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin