Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 444761..445363 Replicon chromosome
Accession NZ_CP013443
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name higB Uniprot ID A0A837UPF4
Locus tag WT26_RS05415 Protein ID WP_059592488.1
Coordinates 445046..445363 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A118IY59
Locus tag WT26_RS05410 Protein ID WP_059592487.1
Coordinates 444761..445042 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS05380 440528..441148 + 621 WP_006477110.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -
WT26_RS05385 441145..442527 + 1383 WP_155630833.1 cytochrome bc complex cytochrome b subunit -
WT26_RS05390 442549..443309 + 761 Protein_411 cytochrome c1 -
WT26_RS05395 443403..444014 + 612 WP_006400565.1 glutathione S-transferase N-terminal domain-containing protein -
WT26_RS05400 444087..444596 + 510 WP_069272329.1 ClpXP protease specificity-enhancing factor -
WT26_RS05410 444761..445042 - 282 WP_059592487.1 helix-turn-helix domain-containing protein Antitoxin
WT26_RS05415 445046..445363 - 318 WP_059592488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WT26_RS35245 445594..445899 - 306 WP_080485625.1 hypothetical protein -
WT26_RS05425 445973..446314 - 342 WP_059808466.1 helix-turn-helix domain-containing protein -
WT26_RS05430 446770..447345 - 576 WP_155123062.1 hypothetical protein -
WT26_RS05435 447627..449498 - 1872 WP_060138940.1 hypothetical protein -
WT26_RS37935 450018..450239 + 222 WP_196222159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-82)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12026.23 Da        Isoelectric Point: 10.3463

>T58676 WP_059592488.1 NZ_CP013443:c445363-445046 [Burkholderia cepacia]
MTWHVELIPEATAELLALPPDMRARFLHIAEMLAEFGPQRVGMPHVRPLEGKLWEIRMTGRDGIARAIYVARTGQRLVVL
HVFVKKTQKTPHRAMETACARMKED

Download         Length: 318 bp

>T58676 NZ_CP013443:c445363-445046 [Burkholderia cepacia]
ATGACTTGGCATGTTGAGTTGATACCCGAGGCCACAGCCGAATTGCTGGCGCTGCCGCCCGATATGCGCGCCCGTTTCCT
CCACATCGCAGAGATGCTTGCGGAGTTCGGTCCGCAACGCGTCGGGATGCCCCACGTGCGCCCACTGGAGGGAAAGCTGT
GGGAAATCCGCATGACGGGGCGAGATGGCATCGCCCGGGCGATATACGTTGCACGGACGGGGCAGCGCTTGGTCGTGCTG
CACGTGTTCGTGAAAAAGACGCAGAAGACACCCCACCGAGCCATGGAAACGGCCTGTGCCCGGATGAAGGAGGATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10180.67 Da        Isoelectric Point: 10.6655

>AT58676 WP_059592487.1 NZ_CP013443:c445042-444761 [Burkholderia cepacia]
MTSLATLKKRLLADPATQAEYDAQAPEFAVARELVAARVRAGLTQEQVAERMQTTQSTIARMESGRTMPSLRTLSRYAEA
TGSRAVVRLEVAK

Download         Length: 282 bp

>AT58676 NZ_CP013443:c445042-444761 [Burkholderia cepacia]
ATGACCAGCCTTGCAACCCTGAAGAAGCGCCTGCTGGCCGACCCGGCTACCCAGGCCGAGTATGACGCACAAGCGCCGGA
GTTTGCCGTTGCGCGCGAACTCGTCGCTGCGCGCGTACGTGCCGGATTGACGCAGGAACAGGTGGCCGAGAGGATGCAGA
CGACCCAATCGACCATCGCGCGCATGGAAAGCGGTCGCACGATGCCGTCGCTGCGGACGCTGTCCCGCTATGCCGAGGCG
ACGGGAAGCCGTGCCGTGGTACGCCTCGAGGTCGCGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837UPF4

Antitoxin

Source ID Structure
AlphaFold DB A0A118IY59

References