Detailed information of TA system TA058668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 177961..178598
• Replicon: chromosome
• Accession: NZ_CP013439
• Organism: Burkholderia vietnamiensis strain HI2297

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1B4LE75
• Locus tag: WK31_RS00710
• Protein ID: WP_059735504.1
• Coordinates: 178197..178598 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: WK31_RS00705
• Protein ID: WP_045578624.1
• Coordinates: 177961..178197 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK31_RS00685	173474..174508	+	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-
WK31_RS31260	174569..174895	+	327	WP_069246101.1	hypothetical protein	-
WK31_RS00695	174861..175982	-	1122	WP_069246102.1	ADP-heptose--LPS heptosyltransferase	-
WK31_RS00700	175979..177682	-	1704	WP_069246103.1	thiamine pyrophosphate-binding protein	-
WK31_RS00705	177961..178197	+	237	WP_045578624.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WK31_RS00710	178197..178598	+	402	WP_059735504.1	type II toxin-antitoxin system VapC family toxin	Toxin
WK31_RS00715	178666..180054	-	1389	WP_014722202.1	L-serine ammonia-lyase	-
WK31_RS00720	180085..181221	-	1137	WP_045578623.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14850.01 Da
• Isoelectric Point: 5.6350

>T58668 WP_059735504.1 NZ_CP013439:178197-178598 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAALEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T58668 NZ_CP013439:178197-178598 [Burkholderia vietnamiensis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGCGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9022.15 Da
• Isoelectric Point: 5.7316

>AT58668 WP_045578624.1 NZ_CP013439:177961-178197 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT58668 NZ_CP013439:177961-178197 [Burkholderia vietnamiensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATCCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCGAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Structures

Toxin

• AlphaFold DB: A0A1B4LE75