Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 956558..958305 Replicon chromosome
Accession NZ_CP013418
Organism Burkholderia sp. MSMB0266

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WS78_RS25195 Protein ID WP_059582519.1
Coordinates 957409..958305 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4SHD2
Locus tag WS78_RS25190 Protein ID WP_038744096.1
Coordinates 956558..957412 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS78_RS25170 951778..953268 - 1491 WP_059582508.1 aldehyde dehydrogenase -
WS78_RS25175 953290..954105 - 816 WP_038744102.1 aspartate dehydrogenase -
WS78_RS25180 954098..955771 - 1674 WP_059582509.1 thiamine pyrophosphate-binding protein -
WS78_RS25185 955764..956561 - 798 WP_059582513.1 SDR family oxidoreductase -
WS78_RS25190 956558..957412 - 855 WP_038744096.1 IclR family transcriptional regulator Antitoxin
WS78_RS25195 957409..958305 - 897 WP_059582519.1 alpha/beta fold hydrolase Toxin
WS78_RS25200 958322..958849 - 528 WP_038744200.1 cupin domain-containing protein -
WS78_RS25205 958881..959651 - 771 WP_059582523.1 SDR family oxidoreductase -
WS78_RS25210 959648..960715 - 1068 WP_038744090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS78_RS25215 960750..961061 - 312 WP_038744087.1 hypothetical protein -
WS78_RS25220 961063..961380 - 318 WP_038744084.1 non-heme iron oxygenase ferredoxin subunit -
WS78_RS25225 961815..962903 + 1089 WP_038744082.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-281)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30387.32 Da        Isoelectric Point: 7.6841

>T58627 WP_059582519.1 NZ_CP013418:c958305-957409 [Burkholderia sp. MSMB0266]
MSAISRPAGDASAKPFAELLGCFAERRADAGAAGTIGYREAGDAHGERCPVVLLHGIGSGAASWVRQLDALGATRRVLAW
DAPGYGASSRVAADSPVAADYAAALGAWLDALRIGRCVLVGHSLGAIVAGAFARRAGERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLAALGPQGLADERSANMLSAYASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLSHYHGRIAVAAG
ANDAITPPAACERIAQAAGVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAP

Download         Length: 897 bp

>T58627 NZ_CP013418:c958305-957409 [Burkholderia sp. MSMB0266]
ATGAGCGCAATTTCCAGGCCGGCTGGCGACGCCAGCGCGAAACCGTTCGCGGAGCTGCTCGGCTGCTTTGCCGAGCGCCG
CGCGGACGCGGGCGCCGCGGGCACGATCGGCTACCGCGAGGCGGGCGACGCGCACGGCGAGCGCTGTCCCGTCGTGTTGC
TGCACGGGATCGGATCGGGCGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGCCGCGTGCTCGCGTGG
GATGCGCCCGGCTATGGTGCTTCGTCGCGCGTCGCGGCCGATTCGCCCGTCGCGGCCGATTACGCGGCGGCGCTCGGCGC
ATGGCTCGATGCGTTGCGGATCGGGCGCTGCGTGCTTGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGCGTTCGCGC
GGCGCGCGGGCGAGCGTCTGTCAGGATTGCTGCTGATTTCACCCGCGGGCGGCTACGGCAGCGCGCCCGCCGACGTGCGC
GCCGAGCGGCGCGACAGCCGGCTCGCGCTGCTCGCGGCGCTCGGCCCGCAAGGGCTCGCCGACGAGCGCAGCGCGAACAT
GCTGTCCGCGTACGCGAGCGACGCGGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCGGGCTATGCGC
AGGCGACGCACCTGCTCGCGAACGCGGACCTCGCGTCCGATCTTTCGCATTATCACGGCCGCATCGCGGTCGCGGCCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCACAGGCGGCGGGCGTCGGGTTGCAGGTGATTCCGCG
CGCGGGCCACGCGGGCTATGTCGAAGCGCCCGATGCGTACAGCGCGTTGATCGACGCATTTTGCCGTCAATGCGACGGAT
CGCGAGGTGCGCCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31263.70 Da        Isoelectric Point: 6.6619

>AT58627 WP_038744096.1 NZ_CP013418:c957412-956558 [Burkholderia sp. MSMB0266]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETLDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNDARKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58627 NZ_CP013418:c957412-956558 [Burkholderia sp. MSMB0266]
ATGAGCGAGCCGCTGCTGAAAGACGCCGACGACGCGAAGAATGATTCGAACTACGTAGTACCTGGGCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATCCCGCGCA
CGACGGTGTTCCGCTTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGGGTTGCGGTGCTGCGCCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAGGG
GCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCATGCGTTCGGTTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTACCCCGAACGGGAGCTCGAGCGCGTGACGAAGGCGACGCC
GGAAACCCTCGACGCGCTCTTCGACGTGATTCGCGACGACGCGCGCCGCGGCTACGGGATCGGCAATTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACCGCGCCCGTGCGCAACGACGCGAGGAAGATCGTCGCGGTCGTCACGGTGACGGTGCCGAGG
CCCGAGATCGACGCATCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
CAACTACCGTTCCGACGACGAAAACACCTATTTGAAGGCTTTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4SHD2

References