Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2339265..2340306 | Replicon | chromosome |
| Accession | NZ_CP013389 | ||
| Organism | Burkholderia sp. BDU8 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A1B4G2B8 |
| Locus tag | WS71_RS24940 | Protein ID | WP_066492564.1 |
| Coordinates | 2339265..2339840 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A1B4G2H4 |
| Locus tag | WS71_RS24945 | Protein ID | WP_066492563.1 |
| Coordinates | 2339845..2340306 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WS71_RS24915 | 2334417..2334851 | + | 435 | WP_066492571.1 | hypothetical protein | - |
| WS71_RS24920 | 2334948..2335619 | + | 672 | WP_066492570.1 | Lar family restriction alleviation protein | - |
| WS71_RS24925 | 2335994..2336686 | - | 693 | WP_066492569.1 | TetR/AcrR family transcriptional regulator | - |
| WS71_RS24930 | 2336748..2337425 | + | 678 | WP_066492567.1 | DUF4336 domain-containing protein | - |
| WS71_RS24935 | 2337462..2339096 | + | 1635 | WP_082728093.1 | DUF2306 domain-containing protein | - |
| WS71_RS24940 | 2339265..2339840 | - | 576 | WP_066492564.1 | PIN domain-containing protein | Toxin |
| WS71_RS24945 | 2339845..2340306 | - | 462 | WP_066492563.1 | excisionase family DNA-binding protein | Antitoxin |
| WS71_RS24955 | 2340870..2341784 | - | 915 | WP_066492562.1 | LysR family transcriptional regulator | - |
| WS71_RS24960 | 2341955..2343388 | + | 1434 | WP_082728092.1 | YfcC family protein | - |
| WS71_RS24965 | 2343414..2344619 | + | 1206 | WP_066492557.1 | amidohydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2316624..2360747 | 44123 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22206.53 Da Isoelectric Point: 6.2246
>T58578 WP_066492564.1 NZ_CP013389:c2339840-2339265 [Burkholderia sp. BDU8]
MSSNFTVVYDACVLYPAPLRDLLMHFALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENYE
HLIEVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLETMANQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHFALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENYE
HLIEVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLETMANQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T58578 NZ_CP013389:c2339840-2339265 [Burkholderia sp. BDU8]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATTTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACTAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGTACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTATGAG
CATCTGATCGAGGTGATCGAGTTGCCCGACCCCGACGACCGTCATGTCGTCGCGGCGGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTTCCCAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAGCATCCCGACGACT
TTATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTAATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAGTCAGTGGAAGACTATCTCGAAACGATGGCCAACCAGGGGCTCGTACAGACGGTCGACGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATTTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACTAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGTACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTATGAG
CATCTGATCGAGGTGATCGAGTTGCCCGACCCCGACGACCGTCATGTCGTCGCGGCGGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTTCCCAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAGCATCCCGACGACT
TTATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTAATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAGTCAGTGGAAGACTATCTCGAAACGATGGCCAACCAGGGGCTCGTACAGACGGTCGACGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17183.47 Da Isoelectric Point: 5.5474
>AT58578 WP_066492563.1 NZ_CP013389:c2340306-2339845 [Burkholderia sp. BDU8]
MNTTVTPAVLPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAVLPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT58578 NZ_CP013389:c2340306-2339845 [Burkholderia sp. BDU8]
ATGAACACCACTGTCACTCCTGCGGTCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAGAAGGGAGAGACGCATACAGTCACGCTTC
CGACCTCGGCATTGAGGCTGCTGGACGAGATCCTCCATCAGATCGGAAATGGCAACGCAGTGTCGATCATTCCAATTCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGCGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCCCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGTCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAGAAGGGAGAGACGCATACAGTCACGCTTC
CGACCTCGGCATTGAGGCTGCTGGACGAGATCCTCCATCAGATCGGAAATGGCAACGCAGTGTCGATCATTCCAATTCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGCGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCCCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B4G2B8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B4G2H4 |