Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 2278238..2278800 Replicon chromosome
Accession NZ_CP013389
Organism Burkholderia sp. BDU8

Toxin (Protein)


Gene name mazE Uniprot ID A0A1B4G267
Locus tag WS71_RS24580 Protein ID WP_066493926.1
Coordinates 2278238..2278558 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A1B4G272
Locus tag WS71_RS24585 Protein ID WP_066493925.1
Coordinates 2278552..2278800 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS71_RS35795 2274660..2274806 + 147 WP_159086350.1 hypothetical protein -
WS71_RS35800 2274859..2275029 + 171 WP_159086351.1 hypothetical protein -
WS71_RS24560 2275154..2275957 + 804 WP_203234351.1 N-acetylmuramoyl-L-alanine amidase -
WS71_RS24570 2276486..2277649 + 1164 WP_082728238.1 SH3 domain-containing protein -
WS71_RS24575 2277936..2278172 + 237 WP_159086352.1 hypothetical protein -
WS71_RS24580 2278238..2278558 - 321 WP_066493926.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
WS71_RS24585 2278552..2278800 - 249 WP_066493925.1 antitoxin Antitoxin
WS71_RS24590 2278902..2279090 - 189 WP_108027156.1 tyrosine-type recombinase/integrase -
WS71_RS24595 2279083..2279608 + 526 Protein_2045 error-prone DNA polymerase -
WS71_RS24600 2279734..2280033 + 300 WP_066493923.1 H-NS histone family protein -
WS71_RS24605 2280134..2280526 + 393 WP_066493936.1 DUF2471 family protein -
WS71_RS24610 2280676..2281605 + 930 WP_066493922.1 tyrosine-type recombinase/integrase -
WS71_RS24615 2281676..2282155 + 480 WP_066493921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2236767..2280526 43759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11898.11 Da        Isoelectric Point: 10.6422

>T58576 WP_066493926.1 NZ_CP013389:c2278558-2278238 [Burkholderia sp. BDU8]
VVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRSAPFRIPVTFKRKQGLILLDQIRAVDKVR
LVKREGAVAEKTLLDTLRTLQEVFAE

Download         Length: 321 bp

>T58576 NZ_CP013389:c2278558-2278238 [Burkholderia sp. BDU8]
GTGGTGATGCGCGGGGAAGTCTGGTTGGTCGCGCTCGACCCGACCTTGGGTAGCGAGATACAAAAGACGCGTCCGTGTGT
TGTCGTGTCGCCTCCCGAAATGCACGACCACTTACGGACAGTCATCGTTGCGCCGATGACTTCCAAGGGGCGATCCGCGC
CCTTTCGGATTCCAGTGACGTTCAAGCGCAAACAAGGCTTGATCCTTCTCGACCAGATTCGCGCGGTCGACAAGGTTCGC
CTGGTCAAGAGAGAAGGCGCTGTGGCCGAAAAAACGTTGTTGGACACCCTGCGGACCTTGCAGGAAGTTTTTGCAGAATA
G

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9106.25 Da        Isoelectric Point: 4.4805

>AT58576 WP_066493925.1 NZ_CP013389:c2278800-2278552 [Burkholderia sp. BDU8]
MRTTIRRMGNSQGVLIPKPVLAQLGLENEVEMEVENDTIVLRRPRHKAREGWAEASRALADSGDDALVMGEFSNADDAEL
AW

Download         Length: 249 bp

>AT58576 NZ_CP013389:c2278800-2278552 [Burkholderia sp. BDU8]
ATGAGAACGACGATTCGCAGAATGGGTAATTCGCAAGGCGTGCTGATTCCGAAGCCCGTCCTTGCTCAACTGGGGCTGGA
GAACGAAGTGGAAATGGAAGTCGAAAACGACACGATTGTGCTGCGCCGCCCGAGGCATAAGGCCCGTGAGGGTTGGGCGG
AAGCAAGCAGAGCTCTTGCTGATAGTGGCGACGATGCACTGGTGATGGGCGAGTTTTCGAACGCCGATGACGCGGAGCTT
GCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4G267

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4G272

References