Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 157718..158333 Replicon chromosome
Accession NZ_CP013363
Organism Burkholderia diffusa strain RF2-non-BP9

Toxin (Protein)


Gene name higB Uniprot ID A0A1B4BX26
Locus tag WI26_RS16175 Protein ID WP_069226512.1
Coordinates 157992..158333 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B4BX56
Locus tag WI26_RS16170 Protein ID WP_059593657.1
Coordinates 157718..158005 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI26_RS16140 153222..154043 + 822 WP_069226508.1 SDR family oxidoreductase -
WI26_RS16145 154129..154908 - 780 WP_069226509.1 5'/3'-nucleotidase SurE -
WI26_RS16150 155110..155409 - 300 WP_155623261.1 AzlD family protein -
WI26_RS16155 155402..156139 - 738 WP_069226510.1 AzlC family ABC transporter permease -
WI26_RS16160 156266..156724 + 459 WP_059447568.1 Lrp/AsnC family transcriptional regulator -
WI26_RS16165 156944..157513 + 570 WP_069226511.1 hypothetical protein -
WI26_RS16170 157718..158005 - 288 WP_059593657.1 helix-turn-helix domain-containing protein Antitoxin
WI26_RS16175 157992..158333 - 342 WP_069226512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WI26_RS16180 158763..159623 - 861 WP_069226513.1 hypothetical protein -
WI26_RS16185 159686..160018 - 333 WP_059464954.1 DUF2322 family protein -
WI26_RS16190 160063..160755 - 693 WP_069226514.1 flavin reductase family protein -
WI26_RS16195 160994..161320 + 327 WP_069227746.1 thioredoxin family protein -
WI26_RS16200 161328..161747 + 420 WP_069226515.1 secondary thiamine-phosphate synthase enzyme YjbQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12872.09 Da        Isoelectric Point: 9.8412

>T58500 WP_069226512.1 NZ_CP013363:c158333-157992 [Burkholderia diffusa]
MPANGYEIHFFNARVETAVIALPTTLCARFFALADRMEQYGPNLGEPHTLSMGNGLYEMRLKGAEGIARVFYCAIVDRRI
VMLHCFVKKTQKTPRKELKIARQRLKEVQDGNV

Download         Length: 342 bp

>T58500 NZ_CP013363:c158333-157992 [Burkholderia diffusa]
ATGCCGGCTAACGGATACGAAATTCATTTCTTCAATGCACGCGTGGAAACAGCCGTCATCGCGTTGCCGACAACGCTGTG
TGCTCGTTTTTTTGCGCTCGCCGATCGCATGGAACAGTACGGCCCGAATCTCGGCGAGCCGCACACCTTGTCGATGGGAA
ACGGGCTGTACGAAATGCGACTGAAGGGCGCCGAAGGCATCGCCAGGGTGTTCTACTGCGCGATCGTCGACCGGCGTATC
GTCATGCTGCATTGTTTCGTGAAGAAGACGCAAAAGACGCCCCGGAAGGAACTGAAAATCGCACGCCAACGACTCAAGGA
GGTTCAAGATGGCAACGTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10424.98 Da        Isoelectric Point: 8.0309

>AT58500 WP_059593657.1 NZ_CP013363:c158005-157718 [Burkholderia diffusa]
MATYKALRERALSDPEVHAEYERLNREELALLDMMLAARRDAGLSQADVAERMGTQAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISLA

Download         Length: 288 bp

>AT58500 NZ_CP013363:c158005-157718 [Burkholderia diffusa]
ATGGCAACGTATAAGGCGCTACGCGAGCGTGCCTTGTCTGACCCCGAGGTGCACGCCGAATACGAGCGACTGAACCGCGA
AGAACTCGCACTGCTCGACATGATGCTGGCTGCCCGGCGAGACGCCGGCCTGTCGCAAGCCGACGTAGCCGAGCGCATGG
GCACGCAAGCACCGGCGGTGACGCGACTCGAGCGCGCGCTCGCGACGGGCCAGCATTCACCATCCATCGATACGCTGCGC
AAGTACGCGGCAGCTTGCGGCAAGAAACTCGTGATCTCGCTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4BX26

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4BX56

References