Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1710489..1712236 Replicon chromosome
Accession NZ_CP013359
Organism Burkholderia oklahomensis C6786

Toxin (Protein)


Gene name doc Uniprot ID A0A7U4Y8A2
Locus tag WI23_RS27920 Protein ID WP_010118460.1
Coordinates 1711340..1712236 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7U4UTT2
Locus tag WI23_RS27915 Protein ID WP_010118463.1
Coordinates 1710489..1711343 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI23_RS27895 1705699..1707189 - 1491 WP_010118477.1 aldehyde dehydrogenase -
WI23_RS27900 1707221..1708036 - 816 WP_010118475.1 aspartate dehydrogenase -
WI23_RS27905 1708029..1709702 - 1674 WP_045568477.1 thiamine pyrophosphate-binding protein -
WI23_RS27910 1709695..1710492 - 798 WP_010118465.1 SDR family oxidoreductase -
WI23_RS27915 1710489..1711343 - 855 WP_010118463.1 IclR family transcriptional regulator Antitoxin
WI23_RS27920 1711340..1712236 - 897 WP_010118460.1 alpha/beta fold hydrolase Toxin
WI23_RS27925 1712253..1712780 - 528 WP_010108747.1 cupin domain-containing protein -
WI23_RS27930 1712812..1713582 - 771 WP_010118458.1 SDR family oxidoreductase -
WI23_RS27935 1713579..1714646 - 1068 WP_045568478.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WI23_RS27940 1714681..1714992 - 312 WP_010108743.1 hypothetical protein -
WI23_RS27945 1714994..1715311 - 318 WP_010108742.1 non-heme iron oxygenase ferredoxin subunit -
WI23_RS27955 1715745..1716833 + 1089 WP_010118448.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-278)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30653.73 Da        Isoelectric Point: 7.7117

>T58497 WP_010118460.1 NZ_CP013359:c1712236-1711340 [Burkholderia oklahomensis C6786]
MSAISVTTNDIGATPFAELLERFPERRAAAGAAGAIGYREAGDARGERCPVVLLHGIGSGAASWVRQLDTLGATRRALAW
DAPGYGASSRVAAESPVAADYAASLGAWLDALRIERCVLVGHSLGAIVAGAFARAAGERLSGLLLISPAGGYGGAPADVR
AERRDSRLALLASLGPQGLAEQRSANMLSAHASDAARAWVRWNMARIVPAGYAQATHLLANADLATDLVHYRGRVAVAVG
ADDAITPPAACERIAQAARVGLQVIPRAGHAGYVEAPDTYGALIDAFCRQCDGLRGAA

Download         Length: 897 bp

>T58497 NZ_CP013359:c1712236-1711340 [Burkholderia oklahomensis C6786]
ATGAGCGCGATTTCCGTGACGACGAACGACATCGGCGCGACGCCGTTCGCCGAACTGCTCGAACGCTTTCCCGAGCGGCG
CGCGGCGGCGGGCGCAGCGGGCGCGATCGGTTACCGTGAGGCCGGCGACGCGCGCGGCGAGCGCTGTCCCGTCGTGCTGT
TGCACGGGATCGGGTCGGGCGCGGCGTCGTGGGTGCGGCAGCTCGATACGCTCGGCGCGACGCGCCGTGCGCTCGCGTGG
GACGCGCCCGGCTACGGCGCGTCGTCGCGCGTCGCCGCCGAGTCGCCCGTCGCGGCCGATTACGCGGCGTCGCTCGGCGC
ATGGCTCGACGCGCTGCGGATCGAGCGCTGCGTGCTCGTCGGCCACTCGCTCGGCGCGATCGTCGCCGGTGCGTTCGCGC
GCGCCGCGGGCGAGCGTCTTTCAGGATTGCTGTTGATTTCGCCCGCGGGCGGCTATGGCGGCGCGCCCGCCGACGTGCGG
GCCGAGCGGCGCGACAGCCGTCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGAGCAGCGCAGCGCGAACAT
GCTGTCCGCGCATGCGAGCGACGCGGCGCGCGCATGGGTGCGCTGGAACATGGCGCGGATCGTGCCCGCCGGCTACGCAC
AGGCGACGCACCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGTGCATTACCGCGGCCGCGTCGCGGTCGCGGTCGGC
GCGGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGCAAGCGGCGCGCGTCGGGCTGCAGGTGATCCCGCG
CGCGGGGCACGCGGGCTACGTAGAAGCGCCCGATACGTATGGCGCGCTGATCGACGCGTTTTGCCGTCAGTGCGACGGAC
TGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 30961.43 Da        Isoelectric Point: 6.6554

>AT58497 WP_010118463.1 NZ_CP013359:c1711343-1710489 [Burkholderia oklahomensis C6786]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLCALYPEPALERVTKATPETVDALFGVIRDDARRGYGIGNSAFERDISVVTAPVRNDASKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRPDDENTYLKALGLR

Download         Length: 855 bp

>AT58497 NZ_CP013359:c1711343-1710489 [Burkholderia oklahomensis C6786]
ATGAGCGAACCGCTGCTGAAAGACGCCGACGACGCGAAAAACGATTCGAACTACGTAGTACCGGGGCTCGAGCGCGGTCT
GCGGATTCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTTCTCGAGCGCGCGGACAAGGACCGCAATTATCGATTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
CCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCTCAGTTGTGCGCGCTGTATCCGGAGCCGGCGCTCGAGCGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTCTTCGGCGTGATCCGCGACGACGCGCGGCGCGGCTACGGGATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTTACGGCGCCGGTGCGCAACGACGCGAGCAAGATCGTCGCCGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGTCGCTCGTCGCAGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
GAACTACCGGCCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4Y8A2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4UTT2

References