Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 330744..331594 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ86_RS15785 Protein ID WP_000118351.1
Coordinates 331061..331594 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ86_RS15780 Protein ID WP_001909340.1
Coordinates 330744..331064 (+) Length 107 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ86_RS15735 326080..326562 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ86_RS15745 327370..327639 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ86_RS15750 327633..328154 + 522 WP_071919816.1 DUF2442 domain-containing protein -
ASZ86_RS20065 328211..328324 + 114 WP_001894981.1 hypothetical protein -
ASZ86_RS15760 328293..329129 + 837 WP_000242986.1 hypothetical protein -
ASZ86_RS15765 329294..329932 + 639 WP_000230118.1 HD domain-containing protein -
ASZ86_RS20345 330022..330182 + 161 Protein_290 DUF3709 domain-containing protein -
ASZ86_RS15770 330203..330424 + 222 WP_012705854.1 DUF3709 domain-containing protein -
ASZ86_RS15780 330744..331064 + 321 WP_001909340.1 DUF1778 domain-containing protein Antitoxin
ASZ86_RS15785 331061..331594 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
ASZ86_RS15790 331832..332110 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ86_RS15795 332511..332735 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ86_RS15805 333473..333862 + 390 WP_000491263.1 VOC family protein -
ASZ86_RS15810 333995..334510 + 516 WP_000090008.1 hypothetical protein -
ASZ86_RS15815 334651..335088 + 438 WP_001202554.1 NUDIX pyrophosphatase -
ASZ86_RS15820 335249..335596 + 348 WP_000933409.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304702..436238 131536
- inside Integron - - 309782..435862 126080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(97-153)

Antitoxin

(22-98)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58414 WP_000118351.1 NZ_CP013320:331061-331594 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58414 NZ_CP013320:331061-331594 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11759.53 Da        Isoelectric Point: 4.9309

>AT58414 WP_001909340.1 NZ_CP013320:330744-331064 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 321 bp

>AT58414 NZ_CP013320:330744-331064 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q9KM94


Antitoxin

Source ID Structure

References