Detailed information of TA system TA058119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1722127..1722639
• Replicon: chromosome
• Accession: NZ_CP013216
• Organism: Streptococcus salivarius strain HSISS4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T0T9T6
• Locus tag: HSISS4_RS07795
• Protein ID: WP_021143706.1
• Coordinates: 1722127..1722381 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HSISS4_RS07800
• Protein ID: WP_042762439.1
• Coordinates: 1722385..1722639 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSISS4_RS07775	1717364..1717783	+	420	WP_002891660.1	HIT family protein	-
HSISS4_RS07780	1717780..1718079	+	300	WP_021143709.1	hypothetical protein	-
HSISS4_RS07785	1718111..1718887	-	777	WP_021143708.1	FxLYD domain-containing protein	-
HSISS4_RS07790	1719321..1721426	-	2106	WP_021143707.1	ATP-dependent Clp protease ATP-binding subunit	-
HSISS4_RS07795	1722127..1722381	-	255	WP_021143706.1	Txe/YoeB family addiction module toxin	Toxin
HSISS4_RS07800	1722385..1722639	-	255	WP_042762439.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HSISS4_RS07805	1722781..1723872	-	1092	WP_021143704.1	nucleotidyltransferase	-
HSISS4_RS07810	1723879..1724619	-	741	WP_021143703.1	class I SAM-dependent methyltransferase	-
HSISS4_RS07815	1724824..1725177	-	354	WP_014632696.1	ribosome silencing factor	-
HSISS4_RS07820	1725200..1725790	-	591	WP_021143702.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
HSISS4_RS07825	1725787..1726419	-	633	WP_021143701.1	nicotinate-nucleotide adenylyltransferase	-
HSISS4_RS07830	1726525..1726842	-	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10141.64 Da
• Isoelectric Point: 8.8499

>T58119 WP_021143706.1 NZ_CP013216:c1722381-1722127 [Streptococcus salivarius]
MLLTFTEDAWMDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T58119 NZ_CP013216:c1722381-1722127 [Streptococcus salivarius]
ATGTTACTCACTTTCACTGAAGATGCATGGATGGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGGCGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGTGTCGCCTTTCTCTCTTTC
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9749.02 Da
• Isoelectric Point: 4.8782

>AT58119 WP_042762439.1 NZ_CP013216:c1722639-1722385 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMTQVRAGETQEH
ALKE

Nucleotide

• Length: 255 bp

>AT58119 NZ_CP013216:c1722639-1722385 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTGAAGGATTATATGAAAAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAGTGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGACTCAGGTACGTGCTGGAGAGACTCAAGAGCAT
GCACTAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: A0A074IRU5