Detailed information of TA system TA058118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 705771..706419
• Replicon: chromosome
• Accession: NZ_CP013216
• Organism: Streptococcus salivarius strain HSISS4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: T0UWJ6
• Locus tag: HSISS4_RS03500
• Protein ID: WP_021152058.1
• Coordinates: 705771..706136 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HSISS4_RS03505
• Protein ID: WP_021144391.1
• Coordinates: 706126..706419 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSISS4_RS03480	701261..702403	+	1143	WP_021144396.1	hypothetical protein	-
HSISS4_RS03485	702570..703277	+	708	WP_021144395.1	hypothetical protein	-
HSISS4_RS03490	703475..704629	+	1155	WP_049545955.1	restriction endonuclease subunit S	-
HSISS4_RS03495	704645..705559	+	915	WP_021144393.1	haloacid dehalogenase-like hydrolase	-
HSISS4_RS03500	705771..706136	+	366	WP_021152058.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HSISS4_RS03505	706126..706419	+	294	WP_021144391.1	helix-turn-helix transcriptional regulator	Antitoxin
HSISS4_RS03510	706441..708042	+	1602	WP_021147022.1	type I restriction-modification system subunit M	-
HSISS4_RS03515	708121..709056	+	936	WP_021147021.1	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14558.80 Da
• Isoelectric Point: 10.1433

>T58118 WP_021152058.1 NZ_CP013216:705771-706136 [Streptococcus salivarius]
VHTIYFYKDKQGNQPVLDYMRKLARRDSKDSRIKLNKLNDYIELLSQHGTCAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLRNEE

Nucleotide

• Length: 366 bp

>T58118 NZ_CP013216:705771-706136 [Streptococcus salivarius]
GTGCACACTATTTATTTTTATAAGGACAAACAAGGGAATCAGCCTGTCTTGGACTATATGAGAAAGCTAGCTCGTCGGGA
TAGCAAGGACAGTCGGATCAAACTCAACAAGCTCAATGACTACATCGAACTTTTGAGCCAACATGGTACCTGTGCTGGCC
AACCCTACATCAAGCATCTGGATGCGGAGATCTGGGAGTTGAGACCCTTGCGGGATCGGATTTTATTCGTGGCTTGGCTG
GATGGGAGCTTTGTCTTACTGCATCATTTTGTCAAAAAGACGCAAAAGACACCCAGACGAGAGATCGAGAAAGCCAAGCG
AGAGTTGCAAGATTTGAAGGAAAGAGGGCTAAGAAATGAAGAATAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10730.48 Da
• Isoelectric Point: 5.8962

>AT58118 WP_021144391.1 NZ_CP013216:706126-706419 [Streptococcus salivarius]
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKV

Nucleotide

• Length: 294 bp

>AT58118 NZ_CP013216:706126-706419 [Streptococcus salivarius]
ATGAAGAATAGTGCCATCGGCAGCAATTGGAAAGATGTGAGAGCAGAGCTCTTCACCAAGGAAGAAATCCTTGAAAGTGA
TCTTCGGGTCGCGATTATGACAGAGCTGATTGAGGCTCGGCATGAAAAGGGCATTAGTCAAAAGAAACTAGAAGAACTCA
GTGGGGTTAGCCAACCGGTCATCGCTCGGATGGAGACAGGGAAGACCAGTCCTCAATTGGATACGGTTTTGAAAGTCTTA
GCCAGTCTGGGCAAGACCCTCGCTGTCGTCCCACTGGAACAAGAAAAAGTCTAA

Structures

Toxin

• AlphaFold DB: T0UWJ6