Detailed information of TA system TA058109

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4352055..4352889
• Replicon: chromosome
• Accession: NZ_CP013190
• Organism: Escherichia coli strain FORC_031

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FORC31_RS21775
• Protein ID: WP_140159973.1
• Coordinates: 4352521..4352889 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FORC31_RS21770
• Protein ID: WP_001285580.1
• Coordinates: 4352055..4352423 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC31_RS27440	4347605..4347718	-	114	Protein_4165	IS1 family transposase	-
FORC31_RS21735	4347751..4348719	+	969	WP_023486738.1	IS5 family transposase	-
FORC31_RS21740	4348886..4349665	+	780	Protein_4167	IS3 family transposase	-
FORC31_RS21745	4349667..4349891	-	225	WP_001395295.1	transposase	-
FORC31_RS21750	4350700..4351397	-	698	Protein_4169	IS1 family transposase	-
FORC31_RS21760	4351439..4351618	+	180	WP_001398324.1	hypothetical protein	-
FORC31_RS21765	4351755..4351976	+	222	WP_000691818.1	DUF987 domain-containing protein	-
FORC31_RS21770	4352055..4352423	+	369	WP_001285580.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FORC31_RS21775	4352521..4352889	+	369	WP_140159973.1	TA system toxin CbtA family protein	Toxin
FORC31_RS28615	4352886..4353035	+	150	Protein_4174	hypothetical protein	-
FORC31_RS28620	4353111..4353308	+	198	WP_023563519.1	DUF957 domain-containing protein	-
FORC31_RS21790	4353393..4354235	+	843	WP_001280493.1	DUF4942 domain-containing protein	-
FORC31_RS21795	4354984..4356522	+	1539	WP_044316877.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4347796..4364339	16543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-109)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13616.51 Da
• Isoelectric Point: 9.1652

>T58109 WP_140159973.1 NZ_CP013190:4352521-4352889 [Escherichia coli]
ITQHTRTGGIARPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVSFLVEKYALVRTDQPGFSAC
TRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 369 bp

>T58109 NZ_CP013190:4352521-4352889 [Escherichia coli]
ATTACCCAACACACACGTACGGGAGGCATCGCGCGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTCCCGGTTGCT
GGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTGAAGCTGGCA
TTTCACTGTGTGATGCGGTGAGCTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTCAGCGCCTGT
ACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGACAACTACAG
AACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13670.43 Da
• Isoelectric Point: 6.9462

>AT58109 WP_001285580.1 NZ_CP013190:4352055-4352423 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADSYHLNQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT58109 NZ_CP013190:4352055-4352423 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA