Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 211038..211628 Replicon chromosome
Accession NZ_CP013068
Organism Pannonibacter phragmitetus strain 31801

Toxin (Protein)


Gene name pemK Uniprot ID A0A0U3PAB0
Locus tag APZ00_RS00960 Protein ID WP_058897811.1
Coordinates 211038..211370 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0U3PNZ7
Locus tag APZ00_RS00965 Protein ID WP_058897812.1
Coordinates 211371..211628 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ00_RS00935 206737..207375 - 639 WP_058897806.1 hypothetical protein -
APZ00_RS00940 207572..208567 + 996 WP_058897807.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
APZ00_RS00945 208574..209539 + 966 WP_058897808.1 homoserine kinase -
APZ00_RS00950 209536..210012 + 477 WP_058897809.1 ribonuclease HI -
APZ00_RS00955 210009..211034 + 1026 WP_058897810.1 sphingosine kinase -
APZ00_RS00960 211038..211370 - 333 WP_058897811.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
APZ00_RS00965 211371..211628 - 258 WP_058897812.1 hypothetical protein Antitoxin
APZ00_RS00970 211733..214801 - 3069 WP_208991410.1 EAL domain-containing protein -
APZ00_RS00975 214731..215222 - 492 Protein_198 GNAT family N-acetyltransferase -
APZ00_RS00980 215331..216617 - 1287 WP_058897815.1 insulinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Antitoxin PemI-like

(5-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11840.69 Da        Isoelectric Point: 9.1389

>T57859 WP_058897811.1 NZ_CP013068:c211370-211038 [Pannonibacter phragmitetus]
MKRGDIYLVSLDPTKGREQQGFRPVLVVSPDAFNRLTKAPVVLPITTGGDFARTAGFAVTLMGAGTETTGVIRCDQPRVL
DLGARNARKAESVPQEIIDEVLAKLGTLFQ

Download         Length: 333 bp

>T57859 NZ_CP013068:c211370-211038 [Pannonibacter phragmitetus]
ATGAAACGGGGCGACATCTATCTCGTCTCGCTTGATCCCACGAAAGGGCGCGAGCAGCAGGGGTTCCGCCCTGTGCTCGT
TGTCTCGCCGGATGCATTCAACCGGCTGACAAAGGCACCTGTCGTTCTGCCCATCACGACGGGTGGAGATTTTGCCCGCA
CGGCTGGTTTCGCCGTGACCTTGATGGGCGCGGGCACGGAAACGACGGGTGTTATCCGTTGCGATCAGCCGCGCGTTCTT
GATCTGGGAGCGCGAAACGCCCGCAAGGCTGAAAGCGTGCCGCAGGAAATCATCGACGAAGTCCTGGCCAAGCTCGGAAC
GCTCTTCCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9176.49 Da        Isoelectric Point: 4.5680

>AT57859 WP_058897812.1 NZ_CP013068:c211628-211371 [Pannonibacter phragmitetus]
MHTTSLRKVGGSVMLAVPRALLDTLRLAPGARVGIAIDNGRLVVEPQTKPSYSLEELLAQCDASVDFSEEDKEWLEAPSA
GREVL

Download         Length: 258 bp

>AT57859 NZ_CP013068:c211628-211371 [Pannonibacter phragmitetus]
ATGCACACGACCAGTTTGCGAAAAGTCGGGGGTTCGGTGATGCTTGCCGTTCCAAGGGCGCTCCTCGACACTTTGCGCCT
CGCGCCGGGGGCCCGGGTGGGCATCGCGATAGACAATGGCCGACTCGTTGTGGAGCCGCAAACCAAGCCAAGCTATTCCC
TTGAAGAGCTGCTGGCTCAATGTGACGCTTCGGTCGATTTTTCCGAAGAGGACAAGGAGTGGCTTGAGGCGCCGTCTGCC
GGAAGAGAAGTGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3PAB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3PNZ7

References