Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 104534..105159 Replicon plasmid unnamed1
Accession NZ_CP013047
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0QK53
Locus tag AR325_RS26720 Protein ID WP_060560501.1
Coordinates 104534..104932 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0QKF7
Locus tag AR325_RS26725 Protein ID WP_060560500.1
Coordinates 104932..105159 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS26705 101565..102098 + 534 WP_060560503.1 hypothetical protein -
AR325_RS26710 102101..102310 + 210 WP_033641525.1 hypothetical protein -
AR325_RS26715 102300..104498 + 2199 WP_060560502.1 type IV conjugative transfer system coupling protein TraD -
AR325_RS26720 104534..104932 - 399 WP_060560501.1 tRNA(fMet)-specific endonuclease VapC Toxin
AR325_RS26725 104932..105159 - 228 WP_060560500.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..123171 123171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14708.02 Da        Isoelectric Point: 8.2817

>T57842 WP_060560501.1 NZ_CP013047:c104932-104534 [Serratia marcescens]
MLKYLLDTNTCIFTIKNKPAHVRERFSLNTSRMCISSVTLMELIYGAEKSQAPERNLAVLEGFIARLDVLNYDAAAAAHS
GQIRAELSRKGLPIGPFDLMIAGHARSQGLIVVTNNTREFARVDGLRIEDWC

Download         Length: 399 bp

>T57842 NZ_CP013047:c104932-104534 [Serratia marcescens]
ATGTTGAAGTACCTGCTGGACACCAACACGTGCATCTTCACCATCAAGAACAAACCCGCGCACGTCAGAGAGCGTTTCAG
CCTGAATACGTCGCGCATGTGCATCAGTTCGGTCACGCTGATGGAGCTGATTTACGGCGCGGAGAAAAGTCAGGCACCGG
AACGCAACCTGGCTGTGCTCGAGGGGTTCATTGCGCGCCTTGACGTTCTGAATTACGATGCCGCCGCCGCCGCACACAGC
GGTCAAATCCGGGCCGAATTGAGCCGAAAAGGGCTCCCCATTGGCCCATTCGATTTGATGATTGCCGGTCACGCCCGCAG
CCAGGGGCTGATTGTGGTCACCAACAACACACGGGAGTTTGCACGTGTTGATGGATTGCGCATCGAAGATTGGTGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8469.53 Da        Isoelectric Point: 4.3719

>AT57842 WP_060560500.1 NZ_CP013047:c105159-104932 [Serratia marcescens]
METTVFLSNRSQAVRLPKAVALPDDVKRVEIIAVGRTRIITPAGESWDSWFDGEDVSADFMTSRDQPPMQEREAF

Download         Length: 228 bp

>AT57842 NZ_CP013047:c105159-104932 [Serratia marcescens]
ATGGAAACAACCGTATTTCTCAGCAACCGTAGCCAGGCCGTTCGTCTGCCCAAAGCGGTGGCGCTGCCTGACGACGTCAA
ACGCGTGGAGATCATCGCAGTTGGCCGCACCCGCATCATTACACCGGCCGGCGAAAGCTGGGACAGCTGGTTCGACGGTG
AGGATGTCAGCGCCGATTTCATGACGTCGCGCGACCAACCACCGATGCAAGAGCGGGAGGCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QK53

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0QKF7

References