Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4073072..4073728 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name vapC Uniprot ID A0A086GBH4
Locus tag AR325_RS19720 Protein ID WP_033632382.1
Coordinates 4073072..4073461 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086GBH3
Locus tag AR325_RS19725 Protein ID WP_033632381.1
Coordinates 4073465..4073728 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS19705 4069539..4070969 + 1431 WP_060560043.1 multidrug transporter subunit MdtD -
AR325_RS19710 4070966..4072348 + 1383 WP_060560044.1 two-component system sensor histidine kinase BaeS -
AR325_RS19715 4072348..4073064 + 717 WP_004941568.1 two-component system response regulator BaeR -
AR325_RS19720 4073072..4073461 - 390 WP_033632382.1 type II toxin-antitoxin system VapC family toxin Toxin
AR325_RS19725 4073465..4073728 - 264 WP_033632381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AR325_RS19730 4074066..4074404 + 339 WP_004941561.1 YegP family protein -
AR325_RS19735 4074583..4075935 + 1353 WP_060560045.1 tRNA 5-hydroxyuridine modification protein YegQ -
AR325_RS19740 4076405..4077310 + 906 WP_044030681.1 lipid kinase YegS -
AR325_RS19745 4077480..4078694 + 1215 WP_060560046.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14353.58 Da        Isoelectric Point: 8.4983

>T57835 WP_033632382.1 NZ_CP013046:c4073461-4073072 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T57835 NZ_CP013046:c4073461-4073072 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTTATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCGTTACGGTGTGGCTAAACGGCGGAGCAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCCTGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10089.34 Da        Isoelectric Point: 4.6702

>AT57835 WP_033632381.1 NZ_CP013046:c4073728-4073465 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT57835 NZ_CP013046:c4073728-4073465 [Serratia marcescens]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAACATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCCTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086GBH4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GBH3

References