Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 526011..526527 Replicon chromosome
Accession NZ_CP012999
Organism Enterobacter sp. E20

Toxin (Protein)


Gene name relE Uniprot ID A0A7W2VUY1
Locus tag NI40_RS02485 Protein ID WP_033144499.1
Coordinates 526243..526527 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag NI40_RS02480 Protein ID WP_008501400.1
Coordinates 526011..526253 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI40_RS02465 522013..522753 + 741 WP_033144496.1 KDGP aldolase family protein -
NI40_RS02470 522867..524003 + 1137 WP_039261069.1 lactonase family protein -
NI40_RS02475 524023..525933 + 1911 WP_039261071.1 BglG family transcription antiterminator -
NI40_RS02480 526011..526253 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NI40_RS02485 526243..526527 + 285 WP_033144499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NI40_RS02490 526531..526995 - 465 WP_039261072.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NI40_RS02495 527124..529262 - 2139 WP_032662478.1 anaerobic ribonucleoside-triphosphate reductase -
NI40_RS02500 529639..531282 - 1644 WP_039261073.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.3350

>T57669 WP_033144499.1 NZ_CP012999:526243-526527 [Enterobacter sp. E20]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVSPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T57669 NZ_CP012999:526243-526527 [Enterobacter sp. E20]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGCAGACTGTAAAAGACCAGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAGCCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT57669 WP_008501400.1 NZ_CP012999:526011-526253 [Enterobacter sp. E20]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT57669 NZ_CP012999:526011-526253 [Enterobacter sp. E20]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTATTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACCATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2VUY1

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References