Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 983040..984283 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name pezA Uniprot ID A0A8D4CZB7
Locus tag APQ97_RS04805 Protein ID WP_002935066.1
Coordinates 983040..983807 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag APQ97_RS04810 Protein ID WP_002935067.1
Coordinates 983807..984283 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS04790 979428..979793 - 366 WP_002935058.1 MobC family plasmid mobilization relaxosome protein -
APQ97_RS04795 979803..980162 - 360 WP_002935059.1 hypothetical protein -
APQ97_RS04800 980497..983004 - 2508 WP_053866460.1 AAA family ATPase -
APQ97_RS04805 983040..983807 - 768 WP_002935066.1 zeta toxin family protein Toxin
APQ97_RS04810 983807..984283 - 477 WP_002935067.1 helix-turn-helix domain-containing protein Antitoxin
APQ97_RS04815 984353..984643 - 291 WP_002935069.1 hypothetical protein -
APQ97_RS04820 984693..985082 - 390 WP_002935071.1 hypothetical protein -
APQ97_RS04825 985079..985306 - 228 WP_002935073.1 hypothetical protein -
APQ97_RS04830 985360..986436 - 1077 WP_002935075.1 toprim domain-containing protein -
APQ97_RS04835 986499..988355 - 1857 WP_001820670.1 recombinase family protein -
APQ97_RS04840 988410..988601 - 192 WP_001820669.1 hypothetical protein -
APQ97_RS04845 988673..988903 - 231 WP_001206986.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) - 968950..1026249 57299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 28956.86 Da        Isoelectric Point: 5.6977

>T57455 WP_002935066.1 NZ_CP012911:c983807-983040 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Download         Length: 768 bp

>T57455 NZ_CP012911:c983807-983040 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18273.67 Da        Isoelectric Point: 4.3971

>AT57455 WP_002935067.1 NZ_CP012911:c984283-983807 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT57455 NZ_CP012911:c984283-983807 [Streptococcus suis]
ATGATTGGAGACAATATCAAGTCGCTACGCCGAACACATGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References