Detailed information of TA system TA057251

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1225586..1227018
• Replicon: chromosome
• Accession: NZ_CP012805
• Organism: Streptococcus anginosus strain J4211

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: SanJ4211_RS06125
• Protein ID: WP_057489712.1
• Coordinates: 1226173..1227018 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: SanJ4211_RS06120
• Protein ID: WP_057489711.1
• Coordinates: 1225586..1226176 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SanJ4211_RS06120	1225586..1226176	+	591	WP_057489711.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
SanJ4211_RS06125	1226173..1227018	+	846	WP_057489712.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SanJ4211_RS06130	1227115..1229901	-	2787	WP_057489713.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32627.10 Da
• Isoelectric Point: 5.1971

>T57251 WP_057489712.1 NZ_CP012805:1226173-1227018 [Streptococcus anginosus]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEAILKKLSQSSYSNHYIFKGGFLLSNVIGLESRSTVDIDFLFHKQTLSEE
NIQQQLEEILTESKDGIQFSIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPYPATYDYKAIFDDDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKDDIDFSQLKIACERTFSYRETELDFNKIIELLERFKSDS
IQQQQWQNYSKKYSYTKDILFTDILNEIISLLIALNSNHNV

Nucleotide

• Length: 846 bp

>T57251 NZ_CP012805:1226173-1227018 [Streptococcus anginosus]
ATGAATAAAGCAAAATTAACAGCACTCTGCCATAAAATATCGAAGAATACTGGATTAACTTTTAATTCCGTCATGACCTA
TTACTTTCTTGAAGCTATTCTGAAAAAATTAAGTCAGAGTTCTTATTCGAATCACTATATTTTTAAAGGTGGATTCCTAC
TTTCAAACGTCATTGGGCTTGAATCTCGCAGCACTGTTGATATTGACTTTCTGTTTCATAAACAAACTTTATCAGAAGAA
AATATTCAACAACAGCTTGAAGAAATTTTAACTGAATCGAAAGATGGTATTCAATTTTCAATTCAATCCATAACAGCTAT
TAAGGAAAGCGATGATTATGGTGGTTACCGAGCAACCATTTTATGTCAACTCGAAAATATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGACATTGTCACACCTTACCCTGCTACCTATGACTACAAAGCCATTTTTGATGATGACAATTTTCCA
ATCATTGCTTATACGATTGAAACAATCTTAGCTGAAAAACTCCAAACCATTTATTCACGAAATTTCTTGAACAGTCGCAG
CAAAGATTTTTACGATGTCTATATCCTTTCAAAGCTAAAGAAAGATGACATTGATTTTTCACAATTAAAAATTGCTTGTG
AAAGAACCTTTTCCTATCGTGAAACTGAACTCGATTTCAATAAAATCATTGAACTACTGGAGAGATTCAAATCTGACTCT
ATTCAACAGCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGACATTCTATTCACAGATATACTTAATGA
GATTATCAGCCTCTTGATAGCTCTCAATTCTAATCATAACGTTTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23006.45 Da
• Isoelectric Point: 7.3130

>AT57251 WP_057489711.1 NZ_CP012805:1225586-1226176 [Streptococcus anginosus]
MSKKELLLEYLDSHNGMITHRDCKKLGIPTIYLTRLENEGVIFRVDKGIYLSSSGDYDEYYFFQYRYPRTVFSHISALYL
QGLTDEIPQYFEVTVPKDYRFRNTPLNLNIHTISKDIVNLGVISVKTPMGNTVNVYNFERVLCDFILNRDSIDAELFVKT
LQTYSNFPKKNLSKLYEYAQKLNILDEVKRTLEVLL

Nucleotide

• Length: 591 bp

>AT57251 NZ_CP012805:1225586-1226176 [Streptococcus anginosus]
ATGTCTAAAAAAGAATTGTTACTTGAGTACTTAGACAGTCACAATGGCATGATTACTCATAGAGATTGTAAAAAATTAGG
TATTCCAACCATTTATCTAACTAGACTAGAAAACGAAGGGGTTATCTTTAGGGTCGATAAAGGAATCTATCTGTCCTCTA
GTGGAGATTATGATGAATACTATTTCTTTCAGTATCGTTACCCCAGAACTGTTTTTTCTCATATCTCTGCTCTTTATCTA
CAGGGACTTACAGATGAAATTCCTCAATATTTTGAAGTAACAGTTCCAAAGGACTACCGTTTTAGGAATACACCATTAAA
TTTAAATATTCACACTATTTCTAAAGATATTGTCAACCTAGGGGTCATCAGTGTAAAAACTCCAATGGGAAACACCGTTA
ACGTTTATAATTTTGAACGTGTTCTGTGTGATTTTATCCTTAATCGAGATAGCATTGATGCTGAGCTATTTGTTAAAACA
CTTCAGACTTATAGCAACTTCCCTAAAAAAAATCTCTCAAAGCTCTATGAATATGCTCAAAAACTGAATATCTTAGATGA
AGTTAAACGAACCTTGGAGGTACTACTATGA