Detailed information of TA system TA057038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3975695..3976386
• Replicon: chromosome
• Accession: NZ_CP012697
• Organism: Microbacterium sp. No. 7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AOA12_RS18380
• Protein ID: WP_054686168.1
• Coordinates: 3975695..3976099 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0P0DXX4
• Locus tag: AOA12_RS18385
• Protein ID: WP_054686172.1
• Coordinates: 3976096..3976386 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOA12_RS18355	3970736..3971521	+	786	WP_054686154.1	ABC transporter ATP-binding protein	-
AOA12_RS18360	3971509..3972312	+	804	WP_054686156.1	ABC transporter ATP-binding protein	-
AOA12_RS18365	3972309..3973193	+	885	WP_054686159.1	branched-chain amino acid ABC transporter permease	-
AOA12_RS18370	3973186..3974361	+	1176	WP_054686162.1	branched-chain amino acid ABC transporter permease	-
AOA12_RS18375	3974348..3975604	+	1257	WP_156366578.1	ABC transporter substrate-binding protein	-
AOA12_RS18380	3975695..3976099	-	405	WP_054686168.1	type II toxin-antitoxin system VapC family toxin	Toxin
AOA12_RS18385	3976096..3976386	-	291	WP_054686172.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AOA12_RS18390	3976475..3977353	+	879	WP_054686178.1	formyltetrahydrofolate deformylase	-
AOA12_RS18395	3977856..3978800	-	945	WP_054686181.1	serine hydrolase	-
AOA12_RS18400	3978800..3980770	-	1971	WP_054686184.1	peptidase M13	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-95)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14459.24 Da
• Isoelectric Point: 4.3141

>T57038 WP_054686168.1 NZ_CP012697:c3976099-3975695 [Microbacterium sp. No. 7]
VIVDTSALVAMIQREDGADVIEECMLAHPSRMSAATLVETRVVVNGRTGAAGLLRLAALLRRLGTEVVPFDEAQADVAGE
AYRDYGRGSGHPARLNLGDTYSYALAYVNDEPLLYVGDDFARTDIRSALEEYAP

Nucleotide

• Length: 405 bp

>T57038 NZ_CP012697:c3976099-3975695 [Microbacterium sp. No. 7]
GTGATCGTCGACACTTCCGCGCTCGTCGCAATGATCCAACGCGAAGACGGTGCCGATGTGATCGAGGAATGCATGCTCGC
GCATCCTTCGAGGATGTCGGCGGCAACGCTCGTGGAGACGCGAGTCGTCGTCAACGGCCGAACCGGTGCCGCGGGGCTTC
TGCGGCTTGCGGCGCTTCTGCGCAGACTGGGCACCGAGGTGGTGCCCTTCGACGAGGCCCAGGCGGATGTGGCCGGGGAG
GCCTACAGGGACTACGGCCGCGGCTCCGGCCACCCCGCCCGCCTGAACCTGGGCGACACCTACAGCTACGCCCTCGCATA
CGTCAACGACGAGCCGCTGCTCTACGTCGGCGACGACTTCGCGCGCACCGACATCCGTTCGGCGCTGGAGGAGTACGCGC
CGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11048.42 Da
• Isoelectric Point: 6.2383

>AT57038 WP_054686172.1 NZ_CP012697:c3976386-3976096 [Microbacterium sp. No. 7]
MSLNIKNERTHALVRELAALTGMSQTSAVEDAVRRRLEELRGAKPAVPRYSDEEIARRRAAVTRIIDEFHAETTQEQRDA
MRDHGDWLYDEMGLPK

Nucleotide

• Length: 291 bp

>AT57038 NZ_CP012697:c3976386-3976096 [Microbacterium sp. No. 7]
ATGAGCCTCAACATCAAGAACGAGCGGACCCACGCGCTCGTGCGCGAGCTCGCGGCGCTCACGGGGATGAGCCAGACGAG
CGCCGTGGAGGATGCCGTCCGCCGGCGGCTGGAAGAGCTGCGGGGTGCGAAGCCCGCTGTGCCGCGATACTCCGATGAAG
AGATCGCACGCCGGCGTGCGGCGGTCACCCGCATCATCGACGAGTTCCATGCGGAGACGACGCAGGAACAGCGAGACGCG
ATGCGCGACCACGGTGACTGGCTGTACGACGAGATGGGTCTGCCGAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0P0DXX4