Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 948444..949087 Replicon chromosome
Accession NZ_CP012697
Organism Microbacterium sp. No. 7

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0DLR0
Locus tag AOA12_RS04235 Protein ID WP_054680619.1
Coordinates 948692..949087 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0E525
Locus tag AOA12_RS04230 Protein ID WP_054680616.1
Coordinates 948444..948695 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOA12_RS04215 943793..944455 + 663 WP_054680606.1 response regulator transcription factor -
AOA12_RS04220 944829..945857 + 1029 WP_054680610.1 non-homologous end-joining DNA ligase -
AOA12_RS04225 945923..948358 + 2436 WP_054680613.1 UvrD-helicase domain-containing protein -
AOA12_RS04230 948444..948695 + 252 WP_054680616.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AOA12_RS04235 948692..949087 + 396 WP_054680619.1 type II toxin-antitoxin system VapC family toxin Toxin
AOA12_RS04240 949244..949969 - 726 WP_082405921.1 MerR family transcriptional regulator -
AOA12_RS04245 950042..950461 + 420 WP_054680622.1 hypothetical protein -
AOA12_RS04250 950495..951199 - 705 WP_054680624.1 GNAT family N-acetyltransferase -
AOA12_RS04255 951436..952458 + 1023 WP_054680629.1 SseB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14204.99 Da        Isoelectric Point: 4.8940

>T57036 WP_054680619.1 NZ_CP012697:948692-949087 [Microbacterium sp. No. 7]
VIIDTSAIVAVIDGETDAEAVARCISSAPRLAISAATLVELTGVLMRYRRPELHAAVDRRLADWGVEVVPFDAEQSRVAR
QAYRDYGRGSGHPARLNLGDCYSYALAAITGDDLLFVGDDFTHTDVRSALR

Download         Length: 396 bp

>T57036 NZ_CP012697:948692-949087 [Microbacterium sp. No. 7]
GTGATCATCGACACCTCGGCGATCGTCGCCGTGATCGACGGCGAGACGGACGCGGAAGCCGTCGCCAGGTGCATCTCGTC
GGCGCCCCGGCTCGCGATCTCGGCCGCGACGCTGGTCGAGCTGACGGGCGTGCTGATGCGATATCGGCGCCCTGAGCTGC
ACGCTGCCGTCGATCGGCGACTCGCCGACTGGGGTGTCGAGGTGGTGCCGTTCGACGCGGAGCAGAGTCGTGTCGCCAGG
CAGGCCTATCGCGACTACGGGCGGGGATCGGGCCATCCGGCTCGCCTCAACCTCGGCGACTGCTACAGCTATGCGCTCGC
CGCCATCACCGGCGACGACCTCCTCTTCGTCGGCGATGACTTCACGCACACCGACGTGCGCTCAGCACTGAGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9468.64 Da        Isoelectric Point: 4.3962

>AT57036 WP_054680616.1 NZ_CP012697:948444-948695 [Microbacterium sp. No. 7]
MSLSIKNPTVLELTRELAAVLGTSQVSALEVALREKLERERRGDDTRFQRIRSDLLDIRELAGDGPARQQIDDDMYDEWG
LPQ

Download         Length: 252 bp

>AT57036 NZ_CP012697:948444-948695 [Microbacterium sp. No. 7]
ATGAGCCTCAGCATCAAGAATCCGACGGTGCTCGAGCTGACGCGCGAGCTGGCCGCGGTGCTCGGCACCAGTCAGGTGAG
TGCGCTCGAAGTCGCGCTCCGCGAGAAGCTCGAGCGAGAGCGCCGGGGCGACGACACGCGGTTCCAGCGCATACGCAGCG
ACCTGCTCGACATCCGCGAGCTGGCCGGTGACGGGCCGGCGCGGCAGCAGATCGACGACGACATGTACGACGAGTGGGGC
CTCCCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0DLR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0E525

References