Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2045541..2046376 Replicon chromosome
Accession NZ_CP012693
Organism Escherichia coli strain FORC_028

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag FORC28_RS10255 Protein ID WP_000854757.1
Coordinates 2045541..2045918 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag FORC28_RS10260 Protein ID WP_001295723.1
Coordinates 2046008..2046376 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC28_RS10220 2041061..2041534 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
FORC28_RS10225 2041732..2042790 + 1059 WP_001200883.1 FUSC family protein -
FORC28_RS10230 2042962..2043291 + 330 WP_000450409.1 DUF496 family protein -
FORC28_RS10235 2043392..2043574 - 183 WP_024167529.1 ethanolamine utilization protein -
FORC28_RS32095 2044028..2045056 - 1029 Protein_1975 IS110 family transposase -
FORC28_RS33005 2045215..2045328 - 114 WP_001161660.1 DUF957 domain-containing protein -
FORC28_RS10250 2045341..2045544 - 204 WP_000761705.1 hypothetical protein -
FORC28_RS10255 2045541..2045918 - 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
FORC28_RS10260 2046008..2046376 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FORC28_RS10270 2046539..2046760 - 222 WP_000692323.1 DUF987 domain-containing protein -
FORC28_RS10275 2046829..2047305 - 477 WP_001186725.1 RadC family protein -
FORC28_RS10280 2047321..2047806 - 486 WP_000849582.1 antirestriction protein -
FORC28_RS10285 2047861..2048679 - 819 WP_001234620.1 DUF945 domain-containing protein -
FORC28_RS10290 2048779..2049012 - 234 WP_001119729.1 DUF905 family protein -
FORC28_RS10295 2049091..2049432 - 342 WP_072097794.1 hypothetical protein -
FORC28_RS10300 2049521..2049925 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
FORC28_RS10305 2049922..2050269 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T57007 WP_000854757.1 NZ_CP012693:c2045918-2045541 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T57007 NZ_CP012693:c2045918-2045541 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT57007 WP_001295723.1 NZ_CP012693:c2046376-2046008 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT57007 NZ_CP012693:c2046376-2046008 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References