Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5097062..5097715 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ABH11_RS23760 Protein ID WP_033645671.1
Coordinates 5097062..5097412 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ABH11_RS23765 Protein ID WP_060706975.1
Coordinates 5097416..5097715 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS23730 5092326..5093015 - 690 WP_060436797.1 trehalose-6-phosphate synthase -
ABH11_RS23735 5093028..5093438 - 411 WP_060443701.1 GNAT family N-acetyltransferase -
ABH11_RS23740 5093468..5094838 - 1371 WP_039567579.1 glutamine synthetase family protein -
ABH11_RS23745 5095084..5095401 + 318 WP_060426418.1 hypothetical protein -
ABH11_RS23750 5095392..5095787 - 396 WP_060430830.1 hypothetical protein -
ABH11_RS23755 5095787..5096790 - 1004 Protein_4764 hypothetical protein -
ABH11_RS23760 5097062..5097412 + 351 WP_033645671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABH11_RS23765 5097416..5097715 + 300 WP_060706975.1 helix-turn-helix transcriptional regulator Antitoxin
ABH11_RS23770 5097705..5098622 - 918 WP_033648568.1 LysR family transcriptional regulator -
ABH11_RS23775 5098791..5099489 + 699 WP_060430838.1 CoA transferase subunit A -
ABH11_RS23780 5099501..5100154 + 654 WP_060706976.1 CoA transferase subunit B -
ABH11_RS23785 5100168..5101352 + 1185 WP_039567563.1 acetyl-CoA C-acetyltransferase -
ABH11_RS23790 5101371..5102294 + 924 WP_039567560.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13546.81 Da        Isoelectric Point: 8.2699

>T56976 WP_033645671.1 NZ_CP012685:5097062-5097412 [Serratia marcescens]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHPNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQYLMCYFKE

Download         Length: 351 bp

>T56976 NZ_CP012685:5097062-5097412 [Serratia marcescens]
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAGCAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCCGGGCCTTCTCTCCGGCGGCCTTTTGTCGACGTGCTGAAAGGTTCGTTGCATCCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCCTTTTTCGCCTTCGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGCCCATTGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11068.79 Da        Isoelectric Point: 8.6981

>AT56976 WP_060706975.1 NZ_CP012685:5097416-5097715 [Serratia marcescens]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKRLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Download         Length: 300 bp

>AT56976 NZ_CP012685:5097416-5097715 [Serratia marcescens]
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAAGGCTGGGCATTTCCC
AGCCTTCGGTCGCGGCCATCGAAGGGCGCGGCAACGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References