Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5050960..5052583 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ABH11_RS23570 Protein ID WP_060706963.1
Coordinates 5051261..5052583 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ABH11_RS25225 Protein ID WP_071883864.1
Coordinates 5050960..5051256 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS23560 5049718..5050239 + 522 WP_060706961.1 hypothetical protein -
ABH11_RS23565 5050236..5050616 + 381 WP_060706962.1 hypothetical protein -
ABH11_RS25225 5050960..5051256 + 297 WP_071883864.1 helix-turn-helix transcriptional regulator Antitoxin
ABH11_RS23570 5051261..5052583 + 1323 WP_060706963.1 type II toxin-antitoxin system HipA family toxin Toxin
ABH11_RS23575 5053052..5056564 + 3513 WP_060706964.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(154-403)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49959.09 Da        Isoelectric Point: 6.7697

>T56975 WP_060706963.1 NZ_CP012685:5051261-5052583 [Serratia marcescens]
MRRSQQRLAIWMNGIPVGYWEKRRGEDRLEYLPEWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIGEQPADIFSIRQRPLAEAKIAEMLRNTTTTLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMRTSIENEWLCSLIVAHYGVPVASTHIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGVSPLRKYQSDGGPGITDIMEILSRSEQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNNQIAWQKCKLAMAVRGSSNHYLLSQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIERVIGLLPDSFPAELAECIFEGIRQQCARLAGR

Download         Length: 1323 bp

>T56975 NZ_CP012685:5051261-5052583 [Serratia marcescens]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAACGGTATTCCGGTGGGATACTGGGAAAAGCGTAGAGGTGAGGA
TCGGCTTGAGTATCTGCCAGAGTGGATTGCAGATAGTCAGGGGAGGCCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTATCGCGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTTTG
GCTATGCGCTATCATGCCGAAAGTCTGGACCCTTTCGACTTATTGGCCGAACTGGGCCGCGACTGTGTTGGTGCCATACA
GCTTCTCGATATCGGTGAGCAACCTGCGGATATATTTTCCATCAGGCAACGCCCGCTGGCAGAGGCGAAAATCGCCGAAA
TGCTCCGCAATACTACCACGACGTTACCGGGGCGACAGGGGCAGGATGACGATCTGCGTTTATCCATCGCCGGCGCTCAG
GAAAAAACGGCGCTGCTGTGGCATGACAACCAATGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATTTTCAAATT
AGCGCTAGGCCTGGTAGGAAACATGCGGGCCGATATGCGCACGTCCATCGAGAATGAATGGCTCTGCTCTCTGATTGTTG
CACACTATGGTGTGCCGGTAGCAAGTACCCATATAGCGCAGTTTGAAGATCAAAAGGCACTGATCGTTGAGCGTTTTGAC
AGGAAACTATCAAGCGATAAACAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAGGAAGTATCAATCAGACGGTGGCCCCGGCATTACCGATATTATGGAAATTCTGAGTCGCTCGGAACAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAAGCGCAGATTATTTTTTGGCTGCTGGCCGCGACAGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCCCAAAATCGTTACCACCTGACGCCACTGTACGATGTGCTATCGGCCTGGCCGCTGATTGGCCCGGGCAA
TAACCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACCATTACCTGCTTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGATTAGGCCAACAGGAGGTTGAGTCCATTATTGAAGAGCTGCTG
GCGGCAACCCCGGGAGTGATTGAACGTGTCATTGGACTACTACCGGATTCGTTCCCGGCCGAATTAGCGGAATGCATTTT
TGAGGGTATCAGGCAGCAGTGCGCGCGGTTGGCAGGGCGATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.53 Da        Isoelectric Point: 8.0100

>AT56975 WP_071883864.1 NZ_CP012685:5050960-5051256 [Serratia marcescens]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVFSSELASPGCE
TEETSTTHIDSPARREQW

Download         Length: 297 bp

>AT56975 NZ_CP012685:5050960-5051256 [Serratia marcescens]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTGCTGGTGGGGTTTCGTAAAGCAAAAGGTCTGAC
GCAAAAAGACGTCTCGGAGAGGCTGGGCGTCACCCAACAGACCTATGCGCGCCTGGAGTCAAACCCTGCATCAGCCAGTC
TGGAGCGCCTTTTTAGGGTGTTTAATGTGCTGGGGATTGAAATGGTGTTTTCCTCAGAGCTTGCCTCTCCGGGATGTGAA
ACGGAAGAAACCTCTACAACTCATATAGACTCGCCTGCAAGACGAGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References