Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2765263..2765923 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BYZ0
Locus tag ABH11_RS13170 Protein ID WP_041035904.1
Coordinates 2765570..2765923 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag ABH11_RS13165 Protein ID WP_033635213.1
Coordinates 2765263..2765565 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS13145 2760885..2761799 - 915 WP_044030856.1 branched-chain amino acid ABC transporter permease -
ABH11_RS13150 2761924..2763042 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
ABH11_RS13160 2763646..2764854 - 1209 WP_041035902.1 aldose 1-epimerase family protein -
ABH11_RS13165 2765263..2765565 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
ABH11_RS13170 2765570..2765923 - 354 WP_041035904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABH11_RS13175 2766363..2767658 + 1296 WP_033647957.1 MFS transporter -
ABH11_RS13180 2767686..2768492 + 807 WP_039565152.1 substrate-binding domain-containing protein -
ABH11_RS13185 2768467..2769366 - 900 WP_033647959.1 LysR family transcriptional regulator -
ABH11_RS13190 2769459..2769824 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13446.27 Da        Isoelectric Point: 8.9000

>T56968 WP_041035904.1 NZ_CP012685:c2765923-2765570 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T56968 NZ_CP012685:c2765923-2765570 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTACTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATCCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT56968 WP_033635213.1 NZ_CP012685:c2765565-2765263 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT56968 NZ_CP012685:c2765565-2765263 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCGGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCAGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BYZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References