Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2704895..2705552 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4RY59
Locus tag ABH11_RS12895 Protein ID WP_060420873.1
Coordinates 2705229..2705552 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0M5M3W3
Locus tag ABH11_RS12890 Protein ID WP_060420390.1
Coordinates 2704895..2705191 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS12865 2700413..2701048 + 636 WP_060439555.1 flavodoxin family protein -
ABH11_RS12870 2701192..2702307 + 1116 WP_060460795.1 glycosyltransferase family 9 protein -
ABH11_RS12875 2702231..2703454 - 1224 WP_060443060.1 O-antigen ligase family protein -
ABH11_RS12880 2703432..2704340 - 909 WP_060419071.1 sugar glycosyltransferase -
ABH11_RS12885 2704645..2704887 + 243 WP_025303447.1 hypothetical protein -
ABH11_RS12890 2704895..2705191 - 297 WP_060420390.1 helix-turn-helix domain-containing protein Antitoxin
ABH11_RS12895 2705229..2705552 - 324 WP_060420873.1 toxin HigB-2 Toxin
ABH11_RS12900 2705617..2706246 - 630 WP_043147651.1 serine-tRNA(Ala) deacylase AlaX -
ABH11_RS12905 2706332..2707267 + 936 WP_039565261.1 LysR family transcriptional regulator -
ABH11_RS12910 2707250..2707897 - 648 WP_033635177.1 DNA oxidative demethylase AlkB -
ABH11_RS12915 2708037..2708915 + 879 WP_060706677.1 EamA family transporter RarD -
ABH11_RS12920 2708917..2709675 - 759 WP_039565253.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12370.15 Da        Isoelectric Point: 8.8132

>T56967 WP_060420873.1 NZ_CP012685:c2705552-2705229 [Serratia marcescens]
MDYLEFIETTVFSRKRAELMKDDDFQAFQSYLLLNHHEGDTISHTGGCKKIRWGLDGKGKRGGVRVIYYLTAPSGRVYLL
LIYRKNEKDDLSGQEKAILRSIVQQLD

Download         Length: 324 bp

>T56967 NZ_CP012685:c2705552-2705229 [Serratia marcescens]
ATGGACTATCTGGAGTTTATCGAAACGACCGTTTTCAGCCGAAAGCGGGCTGAATTGATGAAGGATGATGACTTTCAGGC
TTTCCAAAGCTATTTGCTGTTGAACCATCATGAAGGGGATACGATCAGCCACACGGGCGGATGCAAAAAGATACGCTGGG
GGCTGGACGGAAAGGGAAAACGCGGCGGCGTAAGAGTGATTTATTATCTGACGGCGCCCAGCGGCCGAGTCTATTTATTG
TTGATATACCGTAAAAATGAAAAGGATGATTTATCCGGACAGGAAAAGGCGATATTGAGATCCATCGTTCAACAACTTGA
TTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.00 Da        Isoelectric Point: 10.1906

>AT56967 WP_060420390.1 NZ_CP012685:c2705191-2704895 [Serratia marcescens]
MKKELFDDLVSSMNEMVAIEKGKMTPKSEHVHRHAIPDVKLLRKSRGMKQAEFAKAVGASVGLVQSWEQERRIPSGSALK
LLLLIERNPALLDELLVI

Download         Length: 297 bp

>AT56967 NZ_CP012685:c2705191-2704895 [Serratia marcescens]
ATGAAAAAAGAACTTTTCGACGATTTGGTCAGTAGTATGAACGAAATGGTGGCGATCGAAAAGGGTAAGATGACGCCAAA
ATCCGAGCATGTTCACCGTCATGCTATTCCAGACGTCAAGCTGCTGCGCAAATCCCGTGGGATGAAGCAGGCGGAGTTTG
CCAAGGCTGTGGGGGCCAGCGTGGGACTGGTGCAAAGCTGGGAGCAGGAACGCCGCATACCCTCGGGGTCGGCACTGAAA
CTTCTGCTGCTGATTGAGCGTAACCCGGCATTGCTCGATGAGTTGCTGGTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4RY59

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5M3W3

References