Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1082632..1083157 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4XEJ2
Locus tag ABH11_RS05255 Protein ID WP_033654647.1
Coordinates 1082632..1082916 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag ABH11_RS05260 Protein ID WP_004928423.1
Coordinates 1082906..1083157 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS05230 1077892..1079025 + 1134 WP_033637812.1 putrescine ABC transporter ATP-binding subunit PotG -
ABH11_RS05235 1079050..1080012 + 963 WP_033646669.1 putrescine ABC transporter permease PotH -
ABH11_RS05240 1080009..1080854 + 846 WP_016928360.1 putrescine ABC transporter permease PotI -
ABH11_RS05245 1080959..1081438 + 480 WP_049197168.1 YbjO family protein -
ABH11_RS05250 1081508..1082635 + 1128 WP_043147092.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
ABH11_RS05255 1082632..1082916 - 285 WP_033654647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABH11_RS05260 1082906..1083157 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
ABH11_RS05265 1083259..1083993 - 735 WP_043147094.1 arginine ABC transporter substrate-binding protein -
ABH11_RS05270 1084191..1084859 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
ABH11_RS05275 1084859..1085575 - 717 WP_033637818.1 arginine ABC transporter permease ArtQ -
ABH11_RS05280 1085585..1086316 - 732 WP_033637819.1 arginine ABC transporter substrate-binding protein -
ABH11_RS05285 1086349..1087077 - 729 WP_038884338.1 arginine ABC transporter ATP-binding protein ArtP -
ABH11_RS05290 1087342..1087884 - 543 WP_033637821.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10817.97 Da        Isoelectric Point: 10.6941

>T56958 WP_033654647.1 NZ_CP012685:c1082916-1082632 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T56958 NZ_CP012685:c1082916-1082632 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCTGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCCGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT56958 WP_004928423.1 NZ_CP012685:c1083157-1082906 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT56958 NZ_CP012685:c1083157-1082906 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4XEJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References