Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 414472..415093 Replicon chromosome
Accession NZ_CP012685
Organism Serratia marcescens strain SmUNAM836

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag ABH11_RS01945 Protein ID WP_004940313.1
Coordinates 414472..414675 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag ABH11_RS01950 Protein ID WP_004940312.1
Coordinates 414725..415093 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH11_RS01920 410263..410709 + 447 WP_033647279.1 type II secretion system protein M -
ABH11_RS01925 410746..411561 + 816 WP_049235196.1 A24 family peptidase -
ABH11_RS01930 411558..411920 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
ABH11_RS01935 412174..413604 + 1431 WP_033637339.1 N-acetylglucosamine-binding protein GbpA -
ABH11_RS01940 413657..414175 + 519 WP_033647275.1 cytochrome b/b6 domain-containing protein -
ABH11_RS01945 414472..414675 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
ABH11_RS01950 414725..415093 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
ABH11_RS01955 415252..415605 - 354 WP_033647274.1 hypothetical protein -
ABH11_RS01960 416013..416726 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
ABH11_RS01965 416723..417580 + 858 WP_033637343.1 metal ABC transporter permease -
ABH11_RS01970 417606..418484 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
ABH11_RS24495 418591..418731 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
ABH11_RS01975 418744..418998 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T56956 WP_004940313.1 NZ_CP012685:c414675-414472 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T56956 NZ_CP012685:c414675-414472 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT56956 WP_004940312.1 NZ_CP012685:c415093-414725 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT56956 NZ_CP012685:c415093-414725 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References