Detailed information of TA system TA056905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09907-MazE
• Location: 7457..8058
• Replicon: plasmid pMK04
• Accession: NZ_CP012652
• Organism: Lactiplantibacillus plantarum strain HFC8 isolate Lactobacillus plantarum

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: Q684P1
• Locus tag: AN634_RS14955
• Protein ID: WP_001748110.1
• Coordinates: 7457..7801 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: AN634_RS14960
• Protein ID: WP_060677981.1
• Coordinates: 7795..8058 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN634_RS14925	3406..4068	+	663	WP_003645001.1	amino acid ABC transporter permease	-
AN634_RS14930	4049..4738	+	690	WP_013727072.1	amino acid ABC transporter permease	-
AN634_RS14935	4731..5471	+	741	WP_003645003.1	amino acid ABC transporter ATP-binding protein	-
AN634_RS14940	5492..6346	+	855	WP_060677980.1	transporter substrate-binding domain-containing protein	-
AN634_RS14955	7457..7801	-	345	WP_001748110.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AN634_RS14960	7795..8058	-	264	WP_060677981.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AN634_RS14965	8144..8620	+	477	Protein_10	tyrosine-type recombinase/integrase	-
AN634_RS14970	8847..9026	+	180	Protein_11	hypothetical protein	-
AN634_RS14975	9042..9962	-	921	WP_011373852.1	IS30-like element ISLsa1 family transposase	-
AN634_RS14980	10131..10409	+	279	WP_060677982.1	hypothetical protein	-
AN634_RS17365	10490..10696	-	207	WP_080376312.1	methyltransferase	-
AN634_RS14990	11138..12235	-	1098	WP_060677983.1	replication initiator protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..46011	46011

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 16943.32 Da
• Isoelectric Point: 5.5500

>T56905 WP_001748110.1 NZ_CP012652:c7801-7457 [Lactiplantibacillus plantarum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 345 bp

>T56905 NZ_CP012652:c7801-7457 [Lactiplantibacillus plantarum]
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Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 12969.56 Da
• Isoelectric Point: 5.5500

>AT56905 WP_060677981.1 NZ_CP012652:c8058-7795 [Lactiplantibacillus plantarum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFF

Nucleotide

• Length: 264 bp

>AT56905 NZ_CP012652:c8058-7795 [Lactiplantibacillus plantarum]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: A0A0R2K1X3