Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3983641..3983899 Replicon chromosome
Accession NZ_CP012633
Organism Escherichia coli strain SF-166

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AN204_RS19525 Protein ID WP_000809168.1
Coordinates 3983747..3983899 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3983641..3983698 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN204_RS19510 3979473..3980732 - 1260 WP_001557213.1 hypothetical protein -
AN204_RS19515 3980861..3982354 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
AN204_RS19520 3982374..3983135 - 762 WP_001274823.1 hypothetical protein -
- 3983641..3983698 - 58 - - Antitoxin
AN204_RS19525 3983747..3983899 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AN204_RS19530 3984004..3985134 - 1131 WP_001118464.1 molecular chaperone DnaJ -
AN204_RS19535 3985223..3987139 - 1917 WP_000516135.1 molecular chaperone DnaK -
AN204_RS19540 3987511..3987915 + 405 WP_000843687.1 DUF2541 family protein -
AN204_RS19545 3987941..3988654 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T56866 WP_000809168.1 NZ_CP012633:3983747-3983899 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T56866 NZ_CP012633:3983747-3983899 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT56866 NZ_CP012633:c3983698-3983641 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References