Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4130372..4130630 Replicon chromosome
Accession NZ_CP012631
Organism Escherichia coli strain SF-173

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AN205_RS20560 Protein ID WP_000809168.1
Coordinates 4130478..4130630 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4130372..4130429 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN205_RS20545 4126204..4127463 - 1260 WP_000494924.1 hypothetical protein -
AN205_RS20550 4127592..4129085 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
AN205_RS20555 4129105..4129866 - 762 WP_001274823.1 hypothetical protein -
- 4130372..4130429 - 58 - - Antitoxin
AN205_RS20560 4130478..4130630 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AN205_RS20565 4130735..4131865 - 1131 WP_001118464.1 molecular chaperone DnaJ -
AN205_RS20570 4131954..4133870 - 1917 WP_000516135.1 molecular chaperone DnaK -
AN205_RS20575 4134242..4134646 + 405 WP_000843687.1 DUF2541 family protein -
AN205_RS20580 4134672..4135385 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T56837 WP_000809168.1 NZ_CP012631:4130478-4130630 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T56837 NZ_CP012631:4130478-4130630 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT56837 NZ_CP012631:c4130429-4130372 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References