Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3305650..3306482 Replicon chromosome
Accession NZ_CP012376
Organism Escherichia coli strain GE3

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AKN41_RS16200 Protein ID WP_000854816.1
Coordinates 3306108..3306482 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AKN41_RS16195 Protein ID WP_001285402.1
Coordinates 3305650..3306018 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKN41_RS16160 3302289..3302744 + 456 WP_042110819.1 hypothetical protein -
AKN41_RS24950 3302863..3303074 - 212 Protein_3121 hypothetical protein -
AKN41_RS16175 3303145..3303963 + 819 WP_001234639.1 DUF945 domain-containing protein -
AKN41_RS16180 3304226..3304705 + 480 WP_000706981.1 antirestriction protein -
AKN41_RS16185 3304721..3305197 + 477 WP_001186727.1 RadC family protein -
AKN41_RS16190 3305266..3305487 + 222 WP_000692326.1 DUF987 domain-containing protein -
AKN41_RS16195 3305650..3306018 + 369 WP_001285402.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AKN41_RS16200 3306108..3306482 + 375 WP_000854816.1 type IV toxin-antitoxin system toxin CbtA Toxin
AKN41_RS16205 3306479..3306970 + 492 WP_000976865.1 hypothetical protein -
AKN41_RS16210 3306990..3307187 + 198 WP_000772027.1 DUF957 domain-containing protein -
AKN41_RS16215 3307272..3308114 + 843 WP_001274564.1 DUF4942 domain-containing protein -
AKN41_RS16220 3308395..3308931 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
AKN41_RS16225 3308933..3310111 - 1179 WP_000094989.1 type II secretion system protein GspL -
AKN41_RS16230 3310108..3311085 - 978 WP_000633239.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hlyC / hlyA / hlyB / hlyD / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC 3245508..3375362 129854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14045.05 Da        Isoelectric Point: 9.1493

>T56349 WP_000854816.1 NZ_CP012376:3306108-3306482 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

>T56349 NZ_CP012376:3306108-3306482 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCGCGTCCGTCTCCTGTTGAAATCTGGCAGACACTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13883.62 Da        Isoelectric Point: 6.3165

>AT56349 WP_001285402.1 NZ_CP012376:3305650-3306018 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELILTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT56349 NZ_CP012376:3305650-3306018 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATACTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References