Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4594304..4594875 Replicon chromosome
Accession NZ_CP012331
Organism Alcanivorax xenomutans strain P40

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P40_RS21300 Protein ID WP_080531770.1
Coordinates 4594304..4594582 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag P40_RS21305 Protein ID WP_014996637.1
Coordinates 4594582..4594875 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P40_RS21280 4590114..4590590 - 477 WP_022997273.1 peroxiredoxin -
P40_RS21285 4590789..4592855 - 2067 WP_080531768.1 VIT and VWA domain-containing protein -
P40_RS21290 4593136..4593666 - 531 WP_080531769.1 hypothetical protein -
P40_RS21295 4593697..4594182 - 486 WP_014996635.1 YajQ family cyclic di-GMP-binding protein -
P40_RS21300 4594304..4594582 + 279 WP_080531770.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P40_RS21305 4594582..4594875 + 294 WP_014996637.1 HigA family addiction module antidote protein Antitoxin
P40_RS21310 4594971..4595570 + 600 WP_026948752.1 tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY -
P40_RS21315 4595578..4598343 - 2766 WP_080531771.1 DNA polymerase I -
P40_RS21320 4598598..4599629 - 1032 WP_022997280.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10506.03 Da        Isoelectric Point: 10.3908

>T56304 WP_080531770.1 NZ_CP012331:4594304-4594582 [Alcanivorax xenomutans]
MIKSFRDKGLQRFFTTGSTAGVQTPHAKRLRMQLAALDTATVIEDMDIPGFSLHPLKGKAKGRWSIRVSGNWRLTFEFKD
GNAYVLNYEDYH

Download         Length: 279 bp

>T56304 NZ_CP012331:4594304-4594582 [Alcanivorax xenomutans]
ATGATCAAATCATTCCGCGACAAAGGACTGCAGCGGTTTTTCACCACCGGTTCCACCGCCGGTGTTCAAACCCCTCATGC
CAAGCGTCTGAGGATGCAACTGGCCGCCCTGGATACCGCAACGGTCATTGAGGATATGGATATTCCGGGCTTCTCCTTGC
ACCCCTTGAAAGGAAAAGCAAAGGGGCGCTGGTCCATCCGGGTAAGCGGAAACTGGCGTCTGACCTTTGAATTCAAGGAC
GGCAACGCCTATGTGTTGAACTACGAGGATTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10827.49 Da        Isoelectric Point: 8.6425

>AT56304 WP_014996637.1 NZ_CP012331:4594582-4594875 [Alcanivorax xenomutans]
MNMHHPPHPGEFIREVYLEPHGLSVRALAAKLDISPSSLSRVLNGASGVSPEMALRLSKALGRTPESWLALQDLYDLWQA
RQRINLDKVQAIDFKVA

Download         Length: 294 bp

>AT56304 NZ_CP012331:4594582-4594875 [Alcanivorax xenomutans]
ATGAACATGCACCATCCCCCACACCCCGGTGAGTTCATCCGAGAGGTTTACCTGGAACCTCACGGTTTAAGTGTGCGTGC
GCTGGCGGCAAAGCTGGATATCTCTCCCTCCTCGCTCAGTCGTGTCCTTAACGGGGCCAGCGGCGTGAGCCCGGAAATGG
CTTTGCGCCTATCAAAAGCCCTGGGGCGAACTCCGGAAAGCTGGCTGGCCTTGCAGGACCTTTACGACCTCTGGCAGGCA
CGGCAACGGATCAATCTGGACAAGGTCCAGGCCATCGATTTCAAGGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References