Detailed information of TA system TA056300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1679082..1679731
• Replicon: chromosome
• Accession: NZ_CP012331
• Organism: Alcanivorax xenomutans strain P40

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: P40_RS07955
• Protein ID: WP_080531861.1
• Coordinates: 1679330..1679731 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A154BY15
• Locus tag: P40_RS07950
• Protein ID: WP_063142050.1
• Coordinates: 1679082..1679315 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P40_RS07930	1674338..1676815	+	2478	WP_080530738.1	TonB-dependent siderophore receptor	-
P40_RS07935	1676829..1677089	+	261	WP_080530739.1	hypothetical protein	-
P40_RS07940	1677089..1677394	+	306	WP_080530740.1	hypothetical protein	-
P40_RS07945	1677396..1679009	+	1614	WP_080530741.1	PepSY domain-containing protein	-
P40_RS07950	1679082..1679315	+	234	WP_063142050.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
P40_RS07955	1679330..1679731	+	402	WP_080531861.1	type II toxin-antitoxin system VapC family toxin	Toxin
P40_RS07960	1679894..1682188	+	2295	WP_080530742.1	NADP-dependent malic enzyme	-
P40_RS07965	1682370..1683128	-	759	WP_080530743.1	class II aldolase/adducin family protein	-
P40_RS07970	1683387..1684346	-	960	WP_022994191.1	zinc-binding dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (8-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14670.90 Da
• Isoelectric Point: 7.8524

>T56300 WP_080531861.1 NZ_CP012331:1679330-1679731 [Alcanivorax xenomutans]
MRYLLDTNICIYIINRRPEKVFRHFESLRAGNVAVSSITAAELAFGVAKSGSKRNQQALGKFLAPLEVMAFDEAASERYG
DLRTYLEACGTPIGSLDTLIAAHALALGVTLVTNNLREFRRVPDLALENWVVS

Nucleotide

• Length: 402 bp

>T56300 NZ_CP012331:1679330-1679731 [Alcanivorax xenomutans]
CTGCGCTATTTGCTGGACACCAATATCTGTATTTACATCATCAATCGGCGACCCGAGAAGGTCTTTCGTCACTTCGAATC
ATTGCGTGCCGGCAACGTTGCTGTGTCCAGCATTACCGCCGCGGAATTGGCGTTCGGGGTGGCTAAGAGCGGTTCGAAGC
GCAATCAGCAGGCGCTTGGCAAATTCCTCGCACCGCTCGAAGTGATGGCCTTCGACGAGGCCGCGTCCGAGCGCTATGGC
GACCTGCGTACTTATCTGGAGGCGTGCGGCACACCGATAGGCAGTCTGGATACGCTCATCGCGGCTCACGCGCTCGCTCT
GGGCGTGACCCTGGTGACCAATAATCTCCGTGAGTTTCGGCGGGTTCCGGATCTGGCCCTGGAGAATTGGGTGGTCTCCT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9019.28 Da
• Isoelectric Point: 4.4944

>AT56300 WP_063142050.1 NZ_CP012331:1679082-1679315 [Alcanivorax xenomutans]
MTQFAKIFMSGRSQAVRLPKDLRFEGTEVIARRFGNGVLLLPVERPWDIMREALEEFDADFQMEREQPAAQDRESME

Nucleotide

• Length: 234 bp

>AT56300 NZ_CP012331:1679082-1679315 [Alcanivorax xenomutans]
ATGACCCAGTTCGCTAAAATCTTCATGTCCGGCCGCAGTCAGGCGGTGCGGCTGCCCAAGGATCTGCGCTTCGAAGGGAC
GGAAGTGATCGCCCGGCGTTTTGGTAATGGTGTGTTATTGCTGCCGGTGGAACGCCCTTGGGACATCATGCGCGAGGCTC
TCGAGGAGTTTGACGCGGATTTCCAAATGGAACGGGAGCAACCGGCGGCACAGGATCGAGAGTCAATGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A154BY15