Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4029035..4029654 Replicon chromosome
Accession NZ_CP012252
Organism Klebsiella quasipneumoniae strain HKUOPLA

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AKG92_RS18850 Protein ID WP_002892050.1
Coordinates 4029035..4029253 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AKG92_RS18855 Protein ID WP_002892066.1
Coordinates 4029280..4029654 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKG92_RS18820 4025079..4025342 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
AKG92_RS18825 4025342..4025482 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AKG92_RS18830 4025479..4026177 - 699 WP_053810701.1 GNAT family N-acetyltransferase -
AKG92_RS18835 4026278..4027735 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
AKG92_RS18840 4027704..4028174 - 471 WP_049093338.1 YlaC family protein -
AKG92_RS27125 4028217..4028339 + 123 WP_032431198.1 hypothetical protein -
AKG92_RS18845 4028311..4028877 - 567 WP_004204750.1 maltose O-acetyltransferase -
AKG92_RS18850 4029035..4029253 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AKG92_RS18855 4029280..4029654 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AKG92_RS18860 4030139..4033285 - 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
AKG92_RS18865 4033308..4034501 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T56137 WP_002892050.1 NZ_CP012252:c4029253-4029035 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T56137 NZ_CP012252:c4029253-4029035 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT56137 WP_002892066.1 NZ_CP012252:c4029654-4029280 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT56137 NZ_CP012252:c4029654-4029280 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References