Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1132730..1133350 Replicon chromosome
Accession NZ_CP012162
Organism Enterobacter roggenkampii strain 35734

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag LI67_RS06020 Protein ID WP_008499287.1
Coordinates 1132730..1132948 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LI67_RS06025 Protein ID WP_008499288.1
Coordinates 1132976..1133350 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI67_RS05990 1128744..1129004 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
LI67_RS05995 1129007..1129147 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LI67_RS06000 1129144..1129854 - 711 WP_044597077.1 GNAT family N-acetyltransferase -
LI67_RS06005 1129956..1131416 + 1461 WP_044597076.1 PLP-dependent aminotransferase family protein -
LI67_RS06010 1131388..1131855 - 468 WP_008499285.1 membrane protein -
LI67_RS06015 1131972..1132523 - 552 WP_008499286.1 maltose O-acetyltransferase -
LI67_RS06020 1132730..1132948 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
LI67_RS06025 1132976..1133350 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LI67_RS06030 1133860..1137006 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
LI67_RS06035 1137029..1138222 - 1194 WP_008499290.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T56047 WP_008499287.1 NZ_CP012162:c1132948-1132730 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T56047 NZ_CP012162:c1132948-1132730 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACTCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT56047 WP_008499288.1 NZ_CP012162:c1133350-1132976 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT56047 NZ_CP012162:c1133350-1132976 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References