55670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2749651..2750299 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBPG_RS12810 Protein ID WP_003899414.1
Coordinates 2749651..2749974 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBPG_RS12815 Protein ID WP_003899415.1
Coordinates 2750054..2750299 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS12780 2744974..2745972 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
TBPG_RS12785 2745986..2746450 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBPG_RS12790 2746438..2746689 + 252 WP_003908028.1 hypothetical protein -
TBPG_RS12795 2746860..2748299 - 1440 WP_003901443.1 phage major capsid protein -
TBPG_RS12800 2748307..2748840 - 534 WP_003899412.1 HK97 family phage prohead protease -
TBPG_RS21440 2748993..2749484 - 492 WP_003900541.1 phage terminase small subunit P27 family -
TBPG_RS12810 2749651..2749974 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBPG_RS12815 2750054..2750299 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBPG_RS12820 2750296..2751723 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBPG_RS12825 2751725..2752117 - 393 WP_003899417.1 DUF2742 domain-containing protein -
TBPG_RS12830 2752114..2752374 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBPG_RS12835 2752391..2752753 - 363 WP_003900543.1 hypothetical protein -
TBPG_RS12840 2752756..2753883 - 1128 WP_003899420.1 site-specific integrase -
TBPG_RS12845 2754028..2754255 - 228 WP_003899421.1 hypothetical protein -
TBPG_RS21445 2754252..2754641 - 390 WP_003899422.1 hypothetical protein -
TBPG_RS12850 2754547..2754819 + 273 WP_003900544.1 hypothetical protein -
TBPG_RS12855 2754918..2755151 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2744974..2756970 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T55670 WP_003899414.1 NZ_CP012090:c2749974-2749651 [Mycobacterium tuberculosis W-148]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T55670 NZ_CP012090:c2749974-2749651 [Mycobacterium tuberculosis W-148]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT55670 WP_003899415.1 NZ_CP012090:c2750299-2750054 [Mycobacterium tuberculosis W-148]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT55670 NZ_CP012090:c2750299-2750054 [Mycobacterium tuberculosis W-148]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References