Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 24885..25552 Replicon plasmid pNX59
Accession NZ_CP012061
Organism Xanthomonas sp. ISO98C4

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag AC801_RS24180 Protein ID WP_022557732.1
Coordinates 25136..25552 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag AC801_RS24175 Protein ID WP_022557731.1
Coordinates 24885..25139 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC801_RS25030 20636..21021 - 386 Protein_29 IS3 family transposase -
AC801_RS24165 21054..24083 - 3030 WP_022560486.1 Tn3 family transposase -
AC801_RS24170 24080..24673 - 594 WP_022560487.1 recombinase family protein -
AC801_RS24175 24885..25139 + 255 WP_022557731.1 plasmid stability protein Antitoxin
AC801_RS24180 25136..25552 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
AC801_RS24185 25566..26120 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
AC801_RS24190 26195..26332 - 138 Protein_35 transposase -
AC801_RS24195 26402..26932 - 531 Protein_36 DNA topoisomerase III -
AC801_RS24200 27084..28376 - 1293 WP_033481893.1 hypothetical protein -
AC801_RS24205 28503..29822 - 1320 WP_022557736.1 DUF4990 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..58945 58945
- inside IScluster/Tn - virB1 7557..26332 18775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T55586 WP_022557732.1 NZ_CP012061:25136-25552 [Xanthomonas sp. ISO98C4]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T55586 NZ_CP012061:25136-25552 [Xanthomonas sp. ISO98C4]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT55586 WP_022557731.1 NZ_CP012061:24885-25139 [Xanthomonas sp. ISO98C4]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT55586 NZ_CP012061:24885-25139 [Xanthomonas sp. ISO98C4]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References