Detailed information of TA system TA055405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 13248..13789
• Replicon: plasmid unnamed
• Accession: NZ_CP012003
• Organism: Xanthomonas citri pv. aurantifolii strain 1566

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: AC028_RS22365
• Protein ID: WP_007968778.1
• Coordinates: 13248..13574 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A7W9EDN7
• Locus tag: AC028_RS22370
• Protein ID: WP_033478260.1
• Coordinates: 13571..13789 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC028_RS22325	8483..8764	+	282	WP_088412134.1	type II toxin-antitoxin system YafQ family toxin	-
AC028_RS22330	9084..9485	-	402	WP_007968789.1	hypothetical protein	-
AC028_RS22335	9644..9997	-	354	WP_042676252.1	hypothetical protein	-
AC028_RS22340	10043..10750	-	708	WP_007968786.1	hypothetical protein	-
AC028_RS22345	10747..11202	-	456	WP_007968784.1	hypothetical protein	-
AC028_RS22350	11591..12037	+	447	WP_007968782.1	hypothetical protein	-
AC028_RS22360	12558..13202	+	645	WP_007968779.1	hypothetical protein	-
AC028_RS22365	13248..13574	-	327	WP_007968778.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AC028_RS22370	13571..13789	-	219	WP_033478260.1	antitoxin MazE family protein	Antitoxin
AC028_RS22375	13926..14342	-	417	WP_042676251.1	hypothetical protein	-
AC028_RS22380	14396..14809	-	414	WP_042676250.1	hypothetical protein	-
AC028_RS22385	14820..15395	-	576	WP_042676249.1	phospholipase D family protein	-
AC028_RS22390	15438..16025	-	588	WP_007966857.1	hypothetical protein	-
AC028_RS22395	16071..16958	-	888	WP_011153909.1	lytic transglycosylase domain-containing protein	-
AC028_RS22400	16969..17991	-	1023	WP_007968768.1	P-type DNA transfer ATPase VirB11	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..35521	35521

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-105)

Antitoxin

• Antitoxin MazE-like (5-70)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11732.81 Da
• Isoelectric Point: 9.2550

>T55405 WP_007968778.1 NZ_CP012003:c13574-13248 [Xanthomonas citri pv. aurantifolii]
MMRGDFVTIAMQGDFGKPRPALVIQANQFDEHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLLKPSQVMVDKAMTVKRDK
IGRAFGRVDADALVEIERCLAVFLGIAK

Nucleotide

• Length: 327 bp

>T55405 NZ_CP012003:c13574-13248 [Xanthomonas citri pv. aurantifolii]
ATGATGCGAGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTCATCCAGGCCAA
CCAGTTTGACGAACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTTGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGCCTGCTGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
ATAGGTCGGGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8476.58 Da
• Isoelectric Point: 5.0742

>AT55405 WP_033478260.1 NZ_CP012003:c13789-13571 [Xanthomonas citri pv. aurantifolii]
MAHVNSRVQKHRDALRMAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMEDTDMQRFMDEALADMDGWTE

Nucleotide

• Length: 219 bp

>AT55405 NZ_CP012003:c13789-13571 [Xanthomonas citri pv. aurantifolii]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGTGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGAGGACA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7W9EDN7