Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1398151..1398522 Replicon chromosome
Accession NZ_CP011938
Organism Escherichia coli strain C43(DE3)

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag TZ57_RS07075 Protein ID WP_001317028.1
Coordinates 1398328..1398522 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1398151..1398329 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TZ57_RS07050 1394106..1395479 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
TZ57_RS07055 1395608..1396543 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
TZ57_RS22925 1396595..1397830 - 1236 WP_000040858.1 site-specific integrase -
TZ57_RS07065 1397832..1398047 - 216 WP_000079604.1 excisionase XisR -
TZ57_RS07070 1398126..1398335 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1398151..1398329 + 179 NuclAT_0 - Antitoxin
- 1398151..1398329 + 179 NuclAT_0 - Antitoxin
- 1398151..1398329 + 179 NuclAT_0 - Antitoxin
- 1398151..1398329 + 179 NuclAT_0 - Antitoxin
TZ57_RS07075 1398328..1398522 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
TZ57_RS07080 1398579..1399388 - 810 WP_000166319.1 recombination protein RecT -
TZ57_RS07085 1399381..1400480 - 1100 Protein_1349 PD-(D/E)XK nuclease-like domain-containing protein -
TZ57_RS07090 1400582..1400857 - 276 WP_000632297.1 protein RacC -
TZ57_RS07095 1400932..1401102 - 171 WP_001352098.1 conserved protein, Rac prophage -
TZ57_RS07100 1401102..1401323 - 222 WP_000560223.1 killing protein KilR -
TZ57_RS07105 1401765..1402253 + 489 WP_001312793.1 superinfection exclusion protein B -
TZ57_RS22300 1402250..1402405 - 156 WP_001169151.1 YdaF family protein -
TZ57_RS07110 1402549..1402761 + 213 WP_012775985.1 phage lysis protein EssD -
TZ57_RS07115 1402766..1403110 + 345 WP_000193293.1 YdfR family protein -
TZ57_RS07120 1403076..1403348 - 273 WP_000370546.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1396595..1408660 12065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T55228 WP_001317028.1 NZ_CP011938:c1398522-1398328 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T55228 NZ_CP011938:c1398522-1398328 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT55228 NZ_CP011938:1398151-1398329 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References