Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2434251..2434960 Replicon chromosome
Accession NZ_CP011918
Organism Burkholderia cenocepacia strain ST32 isolate 1232

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TQ36_RS28395 Protein ID WP_077021798.1
Coordinates 2434251..2434724 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TQ36_RS28400 Protein ID WP_058903291.1
Coordinates 2434721..2434960 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TQ36_RS28370 2429784..2430581 + 798 WP_058903290.1 AraC family transcriptional regulator -
TQ36_RS28375 2430758..2431690 + 933 WP_034202133.1 DMT family transporter -
TQ36_RS28380 2431881..2432429 + 549 WP_006485834.1 hypothetical protein -
TQ36_RS28385 2432523..2432657 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
TQ36_RS28390 2432892..2434187 + 1296 WP_006485851.1 aspartate carbamoyltransferase -
TQ36_RS28395 2434251..2434724 - 474 WP_077021798.1 PIN domain-containing protein Toxin
TQ36_RS28400 2434721..2434960 - 240 WP_058903291.1 Arc family DNA-binding protein Antitoxin
TQ36_RS28405 2435257..2437500 + 2244 WP_058903292.1 TonB-dependent siderophore receptor -
TQ36_RS28410 2437504..2438259 + 756 WP_006485843.1 sel1 repeat family protein -
TQ36_RS28415 2438256..2438939 + 684 WP_058903293.1 Fe2+-dependent dioxygenase -
TQ36_RS28420 2439008..2439247 + 240 WP_058903294.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TQ36_RS28425 2439460..2439714 + 255 WP_058903295.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16114.45 Da        Isoelectric Point: 9.1752

>T55201 WP_077021798.1 NZ_CP011918:c2434724-2434251 [Burkholderia cenocepacia]
MILVDTNVMPEPLRREPNAAVIEWLDAQNVETLYLAAIGLAELRSGVAALPEGAGGIGCSRVSGSVCCRCFAVGSCRSTR
RRAGRASLCARTRAAGNAIAVADGYIAATAEANGSIVATRDVAPFQASSSIHAPSGSRSPVLLACRNAKRAVRGGAF

Download         Length: 474 bp

>T55201 NZ_CP011918:c2434724-2434251 [Burkholderia cenocepacia]
ATGATCCTTGTCGATACGAACGTCATGCCCGAACCGCTGCGGCGTGAGCCGAACGCGGCGGTGATCGAGTGGCTCGATGC
GCAGAACGTCGAGACGCTGTATCTCGCGGCGATCGGTCTCGCGGAATTGCGGTCCGGCGTGGCTGCATTGCCGGAGGGCG
CAGGCGGGATTGGCTGCAGCAGAGTATCGGGCAGCGTGTGCTGTCGCTGTTTCGCGGTCGGATCCTGCCGTTCGACGAGG
CGGCGAGCAGGGCGTGCGAGCCTTTGCGCGCGGACGCGTGCCGCGGGCAACGCGATCGCGGTCGCCGATGGCTACATCGC
CGCGACGGCCGAGGCAAACGGCTCGATCGTGGCCACACGCGACGTCGCGCCGTTCCAGGCGTCGTCATCGATCCATGCGC
CGTCCGGTTCGCGATCGCCGGTTCTTTTGGCGTGCCGAAATGCAAAACGCGCCGTGCGTGGCGGCGCGTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8615.79 Da        Isoelectric Point: 4.8228

>AT55201 WP_058903291.1 NZ_CP011918:c2434960-2434721 [Burkholderia cenocepacia]
MPVITVRNLPDEARRALRIRAARHGRSTEAEVRDILEQAVLPGGRLELGTLLAEIGREAGDVDIGVPRDETPTGPMSFE

Download         Length: 240 bp

>AT55201 NZ_CP011918:c2434960-2434721 [Burkholderia cenocepacia]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGCGCGCCGCGCGCTTCGGATCCGTGCGGCCCGACACGGGCGCAG
TACGGAAGCGGAGGTGCGCGACATCCTGGAGCAGGCCGTTCTGCCGGGCGGGCGGCTCGAGCTCGGAACGCTGCTCGCGG
AAATCGGGCGGGAAGCGGGCGATGTCGATATCGGCGTGCCGCGCGACGAGACGCCAACCGGTCCGATGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References