Detailed information of TA system TA055139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3038944..3039460
• Replicon: chromosome
• Accession: NZ_CP011863
• Organism: Enterobacter asburiae strain ATCC 35953

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8I1FZF0
• Locus tag: ACJ69_RS14655
• Protein ID: WP_054829936.1
• Coordinates: 3038944..3039228 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: ACJ69_RS14660
• Protein ID: WP_008501400.1
• Coordinates: 3039218..3039460 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACJ69_RS14640	3034221..3035864	+	1644	WP_059347250.1	alpha,alpha-phosphotrehalase	-
ACJ69_RS14645	3036240..3038378	+	2139	WP_023310191.1	anaerobic ribonucleoside-triphosphate reductase	-
ACJ69_RS14650	3038476..3038940	+	465	WP_048977027.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ACJ69_RS14655	3038944..3039228	-	285	WP_054829936.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACJ69_RS14660	3039218..3039460	-	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ACJ69_RS14665	3039538..3041448	-	1911	WP_059347251.1	BglG family transcription antiterminator	-
ACJ69_RS14670	3041468..3042604	-	1137	WP_059347252.1	lactonase family protein	-
ACJ69_RS14675	3042641..3043381	-	741	WP_029739262.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10908.72 Da
• Isoelectric Point: 10.1988

>T55139 WP_054829936.1 NZ_CP011863:c3039228-3038944 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGETVKDQFKKKLAEVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T55139 NZ_CP011863:c3039228-3038944 [Enterobacter asburiae]
ATGACTTATGAACTGGCATTTGATCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGAGACTGTAAAAGACCAGTTTAA
GAAGAAACTTGCGGAGGTGTTGGTGAATCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTACCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT55139 WP_008501400.1 NZ_CP011863:c3039460-3039218 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT55139 NZ_CP011863:c3039460-3039218 [Enterobacter asburiae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GTGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3