Detailed information of TA system TA055138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2087315..2087975
• Replicon: chromosome
• Accession: NZ_CP011863
• Organism: Enterobacter asburiae strain ATCC 35953

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A376FK36
• Locus tag: ACJ69_RS10300
• Protein ID: WP_029741461.1
• Coordinates: 2087622..2087975 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ACJ69_RS10295
• Protein ID: WP_054830246.1
• Coordinates: 2087315..2087617 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACJ69_RS10275	2083293..2085482	+	2190	WP_059346998.1	TonB-dependent siderophore receptor	-
ACJ69_RS10285	2085776..2086177	-	402	WP_054830247.1	RidA family protein	-
ACJ69_RS10290	2086319..2087239	+	921	WP_059346999.1	LysR family transcriptional regulator	-
ACJ69_RS10295	2087315..2087617	-	303	WP_054830246.1	XRE family transcriptional regulator	Antitoxin
ACJ69_RS10300	2087622..2087975	-	354	WP_029741461.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACJ69_RS10305	2088153..2089046	-	894	WP_059347000.1	LysR family transcriptional regulator	-
ACJ69_RS10310	2089217..2089825	+	609	WP_081051431.1	glutathione S-transferase family protein	-
ACJ69_RS10315	2089869..2090819	-	951	WP_023336219.1	HTH-type transcriptional regulator Cbl	-
ACJ69_RS10320	2090916..2091833	-	918	WP_054830244.1	nitrogen assimilation transcriptional regulator NAC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (25-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13531.36 Da
• Isoelectric Point: 9.0310

>T55138 WP_029741461.1 NZ_CP011863:c2087975-2087622 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLEDTDRASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Nucleotide

• Length: 354 bp

>T55138 NZ_CP011863:c2087975-2087622 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGAGGATACCGATCGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGAGGGCATTTTTCGCCTTTGATCCAAACCGCACCGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11024.80 Da
• Isoelectric Point: 5.7316

>AT55138 WP_054830246.1 NZ_CP011863:c2087617-2087315 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKAGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT55138 NZ_CP011863:c2087617-2087315 [Enterobacter asburiae]
ATGGGAAGAACTCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTGGCTGAGTTACGTGAGAAAGTACAAAAAACGCAAGTAGAGATGGCGCAGGCTCTGGGTATCA
GGCAGCCTACCGTTGCGGTAATGGAAAAGGCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTTGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Structures

Toxin

• AlphaFold DB: A0A376FK36