Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1504429..1505049 Replicon chromosome
Accession NZ_CP011798
Organism Enterobacter ludwigii strain UW5

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag ABT55_RS07090 Protein ID WP_014168902.1
Coordinates 1504429..1504647 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag ABT55_RS07095 Protein ID WP_020885187.1
Coordinates 1504675..1505049 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABT55_RS07060 1500440..1500700 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
ABT55_RS07065 1500703..1500843 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ABT55_RS07070 1500840..1501550 - 711 WP_020885191.1 GNAT family N-acetyltransferase -
ABT55_RS07075 1501651..1503111 + 1461 WP_014168898.1 PLP-dependent aminotransferase family protein -
ABT55_RS07080 1503083..1503550 - 468 WP_020885189.1 extracytoplasmic function sigma factor YlaC -
ABT55_RS07085 1503668..1504219 - 552 WP_020885188.1 maltose O-acetyltransferase -
ABT55_RS07090 1504429..1504647 - 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
ABT55_RS07095 1504675..1505049 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
ABT55_RS07100 1505561..1508707 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
ABT55_RS07105 1508730..1509923 - 1194 WP_032677536.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T55037 WP_014168902.1 NZ_CP011798:c1504647-1504429 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T55037 NZ_CP011798:c1504647-1504429 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT55037 WP_020885187.1 NZ_CP011798:c1505049-1504675 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT55037 NZ_CP011798:c1505049-1504675 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References