Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-RelB
Location 929660..930176 Replicon chromosome
Accession NZ_CP011798
Organism Enterobacter ludwigii strain UW5

Toxin (Protein)


Gene name stbE Uniprot ID A0A7U4MZY1
Locus tag ABT55_RS04430 Protein ID WP_047954962.1
Coordinates 929892..930176 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A839BTQ9
Locus tag ABT55_RS04425 Protein ID WP_020885404.1
Coordinates 929660..929902 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABT55_RS04410 925664..926404 + 741 WP_020882900.1 KDGP aldolase family protein -
ABT55_RS04415 926516..927652 + 1137 WP_047954961.1 lactonase family protein -
ABT55_RS04420 927672..929582 + 1911 WP_014168384.1 BglG family transcription antiterminator -
ABT55_RS04425 929660..929902 + 243 WP_020885404.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ABT55_RS04430 929892..930176 + 285 WP_047954962.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABT55_RS04435 930180..930644 - 465 WP_047954963.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ABT55_RS04440 930783..932921 - 2139 WP_047954964.1 anaerobic ribonucleoside-triphosphate reductase -
ABT55_RS04445 933289..933861 - 573 WP_047954965.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10978.88 Da        Isoelectric Point: 10.3202

>T55036 WP_047954962.1 NZ_CP011798:929892-930176 [Enterobacter ludwigii]
MTYELVFVPRAFKEWTRLGDIVKNQFKKKLANVLVNPWVESARLHGLPDCDKIKFRSQGYRLVYQVQDNVVTVCVIAIGK
REKSAVYHDVNKRL

Download         Length: 285 bp

>T55036 NZ_CP011798:929892-930176 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGTTCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATATCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCTGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AATTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGACGTAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9085.49 Da        Isoelectric Point: 5.1088

>AT55036 WP_020885404.1 NZ_CP011798:929660-929902 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Download         Length: 243 bp

>AT55036 NZ_CP011798:929660-929902 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTCAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4MZY1

Antitoxin

Source ID Structure
AlphaFold DB A0A839BTQ9

References