Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1582013..1582668 Replicon chromosome
Accession NZ_CP011716
Organism Bordetella pertussis strain I088

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag ABC09_RS07720 Protein ID WP_047122780.1
Coordinates 1582013..1582264 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag ABC09_RS07725 Protein ID WP_003809516.1
Coordinates 1582267..1582668 (+) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABC09_RS07695 1577174..1578304 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
ABC09_RS07700 1578539..1579120 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
ABC09_RS07705 1579257..1580321 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
ABC09_RS07710 1580406..1580852 - 447 WP_003819827.1 GFA family protein -
ABC09_RS07715 1581077..1581958 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
ABC09_RS07720 1582013..1582264 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
ABC09_RS07725 1582267..1582668 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ABC09_RS07730 1582688..1582924 + 237 WP_010930404.1 membrane protein -
ABC09_RS07735 1582932..1583411 + 480 WP_010930405.1 disulfide bond formation protein B -
ABC09_RS07740 1583561..1584076 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
ABC09_RS07745 1584079..1585269 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
ABC09_RS07750 1585289..1586326 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
ABC09_RS07755 1586463..1587485 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-82)

Antitoxin

(1-131)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T54904 WP_047122780.1 NZ_CP011716:1582013-1582264 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T54904 NZ_CP011716:1582013-1582264 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT54904 WP_003809516.1 NZ_CP011716:1582267-1582668 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT54904 NZ_CP011716:1582267-1582668 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References