Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4009223..4009785 Replicon chromosome
Accession NZ_CP011642
Organism Serratia marcescens strain CAV1492

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AB188_RS20580 Protein ID WP_047730131.1
Coordinates 4009429..4009785 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag AB188_RS20575 Protein ID WP_004936539.1
Coordinates 4009223..4009432 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB188_RS20550 4005377..4005703 + 327 WP_004936551.1 phage holin, lambda family -
AB188_RS20555 4005693..4006094 + 402 WP_038881240.1 M15 family metallopeptidase -
AB188_RS20560 4006091..4006471 + 381 WP_047730130.1 DUF2570 family protein -
AB188_RS29770 4006452..4006625 + 174 WP_038881246.1 hypothetical protein -
AB188_RS20570 4006841..4009120 + 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
AB188_RS20575 4009223..4009432 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AB188_RS20580 4009429..4009785 + 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AB188_RS20585 4009797..4010735 - 939 WP_047730132.1 homocysteine S-methyltransferase -
AB188_RS20590 4010725..4012134 - 1410 WP_047730133.1 S-methylmethionine permease -
AB188_RS20595 4012312..4013151 + 840 WP_047730134.1 ChaN family lipoprotein -
AB188_RS20600 4013254..4014051 + 798 WP_038881261.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T54745 WP_047730131.1 NZ_CP011642:4009429-4009785 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

>T54745 NZ_CP011642:4009429-4009785 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT54745 WP_004936539.1 NZ_CP011642:4009223-4009432 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT54745 NZ_CP011642:4009223-4009432 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References